Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azathioprine
Drug ID BADD_D00195
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Anstey A, Lear JT: Azathioprine: clinical pharmacology and current indications in autoimmune disorders. BioDrugs. 1998 Jan;9(1):33-47.
Marketing Status Prescription; Discontinued
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D00238
MeSH ID D001379
PubChem ID 2265
TTD Drug ID D07QCE
NDC Product Code 72789-129; 51407-182; 46014-1110; 62991-2189; 12780-0300; 51927-2258; 48954-909; 51552-0779; 15308-0732; 42973-143; 68382-120; 38779-0312; 68382-119; 67877-492; 70771-1139; 65649-241; 68382-118; 67877-494; 54766-590; 68462-502; 0378-1005; 71610-124; 60219-2036; 70771-1140; 51927-0071; 65841-602; 68382-003; 71610-306; 42291-071; 60219-2037; 68084-229; 60219-1076; 70771-1141; 49452-0783; 65649-231; 67877-495; 67877-493; 66122-0009
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H7N7O2S
CAS Registry Number 446-86-6
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionThiopurine S-methyltransferaseP51580Not Available15228171; 9893619; 12525681; 7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Adverse drug reactionInosine triphosphate pyrophosphataseQ9BY32Not Available15167706; 15571265; 15973722
Adverse drug reactionThiopurine S-methyltransferaseP51580Not Available10461478; 12021625; 14566029; 8738760; 12021625
Bone marrow toxicityPurine nucleoside phosphorylaseP00491T781987818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not Available10461478; 12021625; 14566029; 8738760; 12021625
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not Available15228171; 9893619; 12525681; 7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityCytosolic 5'-nucleotidase 1AQ9BXI3Not Available7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cataract06.06.01.001--
Cellulitis11.02.01.001; 23.09.01.0010.004308%Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cervical dysplasia21.06.01.0020.003590%Not Available
Chest discomfort02.02.02.009; 22.02.08.001; 08.01.08.019--Not Available
Chest pain08.01.08.002; 22.02.08.003; 02.02.02.011--Not Available
Chest X-ray abnormal13.19.02.0010.001436%Not Available
Chills15.05.03.016; 08.01.09.0010.015796%
Cholangitis sclerosing10.04.09.002; 09.02.01.0030.002154%Not Available
Cholecystitis09.03.01.0010.002154%
Cholelithiasis09.03.01.0020.002154%Not Available
Cholestasis09.01.01.0010.005026%Not Available
Chromaturia20.02.01.0020.002154%
Chronic lymphocytic leukaemia16.01.06.001; 01.10.06.0010.000937%Not Available
Chronic myeloid leukaemia16.01.07.001; 01.10.07.0010.000375%Not Available
Clostridium difficile colitis07.19.01.004; 11.02.02.0040.001436%Not Available
Coagulopathy01.01.02.0010.007898%Not Available
Colitis07.08.01.0010.021540%
Colitis ulcerative10.02.01.004; 07.08.01.0050.030874%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.000562%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis06.04.01.002; 11.01.06.0120.002154%
Constipation07.02.02.001--
Cough22.02.03.0010.017950%
Crohn's disease10.02.01.005; 07.08.01.0150.127804%Not Available
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005--Not Available
Cryptococcosis11.03.04.0010.001436%Not Available
Cushing's syndrome24.08.04.001; 19.07.03.002; 14.11.01.007; 05.01.01.0010.001436%Not Available
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