Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Azacitidine
Drug ID BADD_D00194
Description A pyrimidine nucleoside analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
Indications and Usage For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.
Marketing Status approved; investigational
ATC Code L01BC07
DrugBank ID DB00928
KEGG ID D03021
MeSH ID D001374
PubChem ID 9444
TTD Drug ID D09FAZ
NDC Product Code 0781-9253; 14096-121; 81955-0012; 16729-306; 55150-393; 63323-771; 68001-527; 69097-368; 69097-805; 71288-153; 72485-201; 65129-1222; 68554-0104; 72606-558; 53183-4011; 43598-678; 59572-102; 51916-350; 83137-0006; 16714-927; 43817-906; 59572-730; 68001-504; 71288-115; 63660-0010; 0781-3253; 42385-312; 66529-0013; 54893-0029; 82920-015; 68001-313; 42385-719; 43598-305; 16714-578; 51991-797; 64679-096; 70121-1237; 63592-1800; 0143-9606; 43598-143; 43598-465; 59572-740
UNII M801H13NRU
Synonyms Azacitidine | 5-Azacytidine | 5 Azacytidine | Azacytidine | Vidaza | NSC-102816 | NSC 102816 | NSC102816
Chemical Information
Molecular Formula C8H12N4O5
CAS Registry Number 320-67-2
SMILES C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
Neoplasm16.16.02.0010.000728%Not Available
Nephropathy20.05.03.0010.000224%Not Available
Nephropathy toxic20.05.03.002; 12.03.01.0100.000224%Not Available
Nervous system disorder17.02.10.0010.000560%Not Available
Neutropenia01.02.03.0040.011585%Not Available
Night sweats23.02.03.006; 08.01.03.0310.000224%Not Available
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.0010.000168%Not Available
Obliterative bronchiolitis12.02.09.036; 10.02.01.096; 22.03.01.0120.000112%Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophageal ulcer07.04.05.0020.000112%
Optic ischaemic neuropathy17.04.05.006; 06.07.03.001; 24.04.10.0010.000112%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pallor23.03.03.031; 08.01.03.032; 24.03.04.001--Not Available
Pancreatitis acute07.18.01.0020.000448%Not Available
Pancytopenia01.03.03.0030.006996%Not Available
Panniculitis23.07.02.002; 10.01.03.0240.000280%Not Available
Pericardial effusion02.06.01.0020.002015%
Pericarditis02.06.02.0010.001791%
Peripheral ischaemia24.04.03.0020.000112%
Peripheral motor neuropathy17.09.03.0040.000112%
Peripheral sensory neuropathy17.09.03.0050.000280%
Petechiae01.01.03.002; 24.07.06.004; 23.06.01.0030.000224%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pharyngitis streptococcal22.07.04.001; 11.02.06.002--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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