Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Auranofin
Drug ID BADD_D00191
Description Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties.
Indications and Usage Used in the treatment of active, progressive or destructive forms of inflammatory arthritis, such as adult rheumatoid arthritis.
Marketing Status Prescription
ATC Code M01CB03
DrugBank ID DB00995
KEGG ID D00237
MeSH ID D001310
PubChem ID 24199313
TTD Drug ID D0L2UN
NDC Product Code 49812-0067; 54766-093
Synonyms Auranofin | Ridaura | SK&F D 39162 | SK&F-39162 | SK&F 39162 | SK&F39162 | Crisinor | Ridauran
Chemical Information
Molecular Formula C20H34AuO9PS
CAS Registry Number 34031-32-8
SMILES CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Diarrhoea (excl infective)Metallothionein-1AP04731Not Available3929564; 3800934; 3807890
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lung disorder22.02.07.001--Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Pancytopenia01.03.03.003--Not Available
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Stomatitis07.05.06.005--
Thrombocytopenia01.08.01.002--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Protein urine present13.13.02.006--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Occult blood positive13.05.02.001--Not Available
Liver function test increased13.03.01.044--Not Available
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