Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Atovaquone
Drug ID BADD_D00186
Description Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Indications and Usage For the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.
Marketing Status Prescription; Discontinued
ATC Code P01AX06
DrugBank ID DB01117
KEGG ID D00236
MeSH ID D053626
PubChem ID 74989
TTD Drug ID D06ZEE
NDC Product Code 62147-0057; 62147-0058; 10702-223; 60687-534; 50268-086; 69452-252; 0173-0665; 68462-421; 0173-0547; 65015-734; 65162-693; 59651-090; 16714-900; 58159-048; 62331-059; 0121-0898; 66039-928; 0904-7064; 66039-840; 70748-299; 65977-0034; 70166-488; 63827-1005; 0121-0888; 66689-062; 0121-1796; 68180-282; 31722-629
Synonyms Atovaquone | 2-(4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone | 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone | Wellvone | Mepron | 566C | compound 566 | 566C80 | hydroxynaphthoquinone 566C80 | 566C80 hydroxynaphthoquinone | hydroxynaphthoquinone, 566C80
Chemical Information
Molecular Formula C22H19ClO3
CAS Registry Number 94015-53-9
SMILES C1CC(CCC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=CC=C4C(=O)C3=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Keratopathy06.06.03.007--Not Available
Laboratory test abnormal13.18.01.001--Not Available
Leukopenia01.02.02.001--Not Available
Methaemoglobinaemia01.05.01.002--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Neutrophil count13.01.06.046--Not Available
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Pain08.01.08.004--
Pancreatitis07.18.01.001--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Renal failure20.01.03.005--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
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