Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Atovaquone
Drug ID BADD_D00186
Description Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Indications and Usage For the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.
Marketing Status Prescription; Discontinued
ATC Code P01AX06
DrugBank ID DB01117
KEGG ID D00236
MeSH ID D053626
PubChem ID 74989
TTD Drug ID D06ZEE
NDC Product Code 62147-0057; 62147-0058; 10702-223; 60687-534; 50268-086; 69452-252; 0173-0665; 68462-421; 0173-0547; 65015-734; 65162-693; 59651-090; 16714-900; 58159-048; 62331-059; 0121-0898; 66039-928; 0904-7064; 66039-840; 70748-299; 65977-0034; 70166-488; 63827-1005; 0121-0888; 66689-062; 0121-1796; 68180-282; 31722-629
Synonyms Atovaquone | 2-(4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone | 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone | Wellvone | Mepron | 566C | compound 566 | 566C80 | hydroxynaphthoquinone 566C80 | 566C80 hydroxynaphthoquinone | hydroxynaphthoquinone, 566C80
Chemical Information
Molecular Formula C22H19ClO3
CAS Registry Number 94015-53-9
SMILES C1CC(CCC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=CC=C4C(=O)C3=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alanine aminotransferase increased13.03.01.003--
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Blood alkaline phosphatase13.04.02.010--Not Available
Blood creatinine increased13.13.01.004--
Body temperature increased13.15.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye disorder06.08.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004--Not Available
The 1th Page    1 2 3    Next   Last    Total 3 Pages