Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Atosiban
Drug ID BADD_D00185
Description Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used intravenously to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. Atobisan was developed by the Swedish company Ferring Pharmaceuticals. It was first reported in the literature in 1985. Atosiban is licensed in proprietary and generic forms for the delay of imminent pre-term birth in pregnant adult women.
Indications and Usage
Marketing Status Not Available
ATC Code G02CX01
DrugBank ID DB09059
KEGG ID D03008
MeSH ID C047046
PubChem ID 5311010
TTD Drug ID D0D8XY
NDC Product Code Not Available
Synonyms atosiban | (Mpa(1)-D-Tyr(Et)(2)-Thr(4)-Orn(8))-oxytocin | oxytocin, 1-deamino-O-ethyltyrosyl(2)-threonyl(4)-ornithine(8)- | oxytocin, 1-deamino-(O-Et-Tyr)(2)-Thr(4)-Orn(8)- | (Mpa(1),D-Tyr(Et)2,Thr(4),Orn(8))oxytocin | 1-deamino-2-Tyr(OEt)-4-Thr-8-Orn-oxytocin | RWJ-22164 | RWJ 22164 | ORF-22164 | ORF 22164
Chemical Information
Molecular Formula C43H67N11O12S2
CAS Registry Number 90779-69-4
SMILES CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)OCC)C(=O)N3CC CC3C(=O)NC(CCCN)C(=O)NCC(=O)N)CC(=O)N)C(C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Body temperature increased13.15.01.001--Not Available
Dermatitis23.03.04.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Gastrointestinal disorder07.11.01.001--Not Available
Headache17.14.01.001--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Immune system disorder10.02.01.001--Not Available
Injection site reaction08.02.03.014; 12.07.03.015--
Insomnia19.02.01.002; 17.15.03.002--
Menopausal symptoms21.02.02.002--Not Available
Multiple pregnancy18.08.03.001--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Rash23.03.13.001--Not Available
Skin disorder23.03.03.007--Not Available
Tachycardia02.03.02.007--Not Available
Uterine atony21.07.03.001--Not Available
Uterine haemorrhage21.07.01.005; 24.07.03.004--
Uterine hypotonus21.07.03.005; 18.07.02.006--Not Available
Vomiting07.01.07.003--
Angiopathy24.03.02.007--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Malnutrition14.03.02.004--Not Available
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