Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Asenapine
Drug ID BADD_D00172
Description Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
Indications and Usage Used for treatment in psychosis, schizophrenia and schizoaffective disorders, manic disorders, and bipolar disorders as monotherapy or in combination.
Marketing Status Prescription
ATC Code N05AH05
DrugBank ID DB06216
KEGG ID D11769
MeSH ID C522667
PubChem ID 9903970
TTD Drug ID D00JRA
NDC Product Code 68968-0172; 62332-544; 42794-016; 62332-199; 46708-199; 42794-017; 46708-544; 68968-0173; 46708-198; 62332-198; 68968-0174
Synonyms asenapine | trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole | asenapine maleate | ORG 5222 | ORG-5222 | 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3-6,7)oxepino(4,5-c)pyrrole | Secuado | Saphris
Chemical Information
Molecular Formula C17H16ClNO
CAS Registry Number 65576-45-6
SMILES CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vision blurred17.17.01.010; 06.02.06.0070.009868%
Vomiting07.01.07.003--
Weight increased13.15.01.0060.041448%
Wheezing22.03.01.0090.003947%
White blood cell count decreased13.01.06.012--
Abasia17.02.05.035; 08.01.02.0070.005921%Not Available
Left ventricular hypertrophy02.04.02.0140.003947%Not Available
Balance disorder17.02.02.0070.003947%Not Available
Idiosyncratic drug reaction08.06.01.002--Not Available
Dysstasia17.02.02.0120.003947%Not Available
Pruritus generalised23.03.12.0030.003947%Not Available
Musculoskeletal stiffness15.03.01.0050.003947%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Depressive symptom19.15.02.003--Not Available
Dysphemia19.19.03.005; 17.02.08.0100.005921%Not Available
Hypoaesthesia oral07.05.05.003; 17.02.06.0210.061185%Not Available
Paraesthesia oral17.02.06.008; 07.05.03.0030.003947%Not Available
Restless legs syndrome17.02.07.008; 15.05.03.0120.007895%Not Available
Angiopathy24.03.02.007--Not Available
Mucosal excoriation12.01.08.019; 08.01.06.0110.003947%Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Eye movement disorder17.02.05.025; 06.05.02.0080.005921%Not Available
Impulse-control disorder19.18.01.0020.003947%Not Available
Inflammation08.01.05.007--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Upper limb fracture15.08.03.018; 12.04.01.0180.003947%Not Available
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