Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Argatroban
Drug ID BADD_D00161
Description Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and prevent the formation of thrombi. Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be obtained prior to administering argatroban.
Indications and Usage Argatroban is indicated for prevention and treatment of thrombosis caused by heparin-induced thrombocytopenia (HIT). It is also indicated for use in patients with, or at risk for, HIT who are undergoing percutaneous coronary intervention.
Marketing Status approved; investigational
ATC Code B01AE03
DrugBank ID DB00278
KEGG ID D00181
MeSH ID C031942
PubChem ID 92722
TTD Drug ID D07UWV
NDC Product Code 42023-182; 0143-9288; 0143-9674; 63323-526; 62227-015; 16729-430; 0143-9559; 70121-1037; 55150-241; 65145-126; 45562-1124; 65219-429; 68083-141; 25021-414; 0143-9377; 0409-1140; 55486-1582; 67457-212; 70333-1191; 76339-118
UNII IY90U61Z3S
Synonyms argatroban | MPQA | (2R,4R)-1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-2-piperidinecarboxylic acid monohydrate | MMTQAP | argatroban monohydrate | argatroban hydrate | Acova | (21R)-argatroban anhydrous | (2R,4R)-1-((2S)-5-((aminoiminomethyl)amino)-1-oxo-2-((((3R)-1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-2-piperidinecarboxylic acid | (21S)-argatroban anhydrous | (2R,4R)-1-((2S)-5-((aminoiminomethyl)amino)-1-oxo-2-((((3S)-1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-2-piperidinecarboxylic acid | (21S)-argatroban | (21R)-argatroban | MD 805 | MD805 | MD-805 | Novastan | argatroban anhydrous | (2R,4R)-1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-2-piperidinecarboxylic acid | MCI 9038 | MCI-9038
Chemical Information
Molecular Formula C23H36N6O5S
CAS Registry Number 74863-84-6
SMILES CC1CCN(C(C1)C(=O)O)C(=O)C(CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute hepatic failure09.01.03.0010.000082%Not Available
Anaemia01.03.02.0010.000164%
Angina pectoris24.04.04.002; 02.02.02.002--
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Aortic stenosis24.04.01.001--Not Available
Aortic thrombosis24.01.09.0010.000082%Not Available
Aortic valve stenosis02.07.03.004--Not Available
Apnoea22.02.01.001--
Arterial thrombosis24.01.01.002--Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.0010.000123%
Cardiac failure02.05.01.0010.000123%
Cardiogenic shock24.06.02.006; 02.05.01.0030.000288%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000452%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000288%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.000082%
Cerebrovascular disorder24.03.05.002; 17.08.02.002--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.12.02.003--Not Available
Coagulopathy01.01.02.0010.000206%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Coronary artery bypass25.03.03.003--Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.006; 12.02.01.036--Not Available
Coronary artery thrombosis24.01.05.002; 02.02.01.007--Not Available
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
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