Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apremilast
Drug ID BADD_D00156
Description Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene.[L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and central nervous system inflammation.[A181216]
Indications and Usage Investigated for use/treatment in psoriasis and psoriatic disorders.
Marketing Status Prescription
ATC Code L04AA32
DrugBank ID DB05676
KEGG ID D08860
MeSH ID C505730
PubChem ID 10151715
TTD Drug ID D07ESC
NDC Product Code 65977-0119; 60219-1410; 60219-1744; 66406-0240; 66039-934; 70518-3155; 12658-0581; 69766-024; 59572-630; 65372-1204; 59572-631; 55513-369; 58032-2030; 59572-632; 53747-077; 55513-137; 59651-150; 53069-1040; 69766-010; 55513-485; 47621-306; 11722-062; 66406-0241; 46708-902; 65129-1383; 55111-993; 53069-1050; 73309-043; 49187-0757; 66406-0242
Synonyms apremilast | Otezla | CC 10004 | CC10004 | CC-10004
Chemical Information
Molecular Formula C22H24N2O7S
CAS Registry Number 253168-86-4
SMILES CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspepsia07.01.02.0010.270389%
Dysphagia07.01.06.003--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dyspnoea02.01.03.002; 22.02.01.004--
Dyspnoea exertional22.02.01.005; 02.01.03.003--Not Available
Dysuria20.02.02.002--
Ear disorder04.03.01.0010.006369%Not Available
Ear haemorrhage24.07.01.004; 04.03.01.002--Not Available
Ear infection11.01.05.001; 04.03.01.0060.055004%Not Available
Ear pain04.03.01.0030.015054%
Eating disorder19.09.01.008; 14.03.01.008--Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Eczema23.03.04.006--
Emotional disorder19.04.02.005--Not Available
Emphysema22.01.02.002--Not Available
Endocarditis11.01.16.001; 02.09.01.001--
Endometrial cancer21.07.02.002; 16.12.02.001--Not Available
Enteritis07.08.03.002--
Enterocolitis07.08.03.003--
Ephelides23.05.01.0050.002895%Not Available
Epicondylitis15.07.01.007; 12.01.07.0010.002316%Not Available
Epilepsy17.12.03.002--Not Available
Episcleritis10.02.01.024; 06.04.07.0010.001158%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.0030.019686%
Erysipelas11.02.06.001; 23.09.01.002--Not Available
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Erythema nodosum23.07.02.001; 10.02.01.020--Not Available
Euphoric mood19.04.02.006--
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