Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apremilast
Drug ID BADD_D00156
Description Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene.[L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and central nervous system inflammation.[A181216]
Indications and Usage Investigated for use/treatment in psoriasis and psoriatic disorders.
Marketing Status Prescription
ATC Code L04AA32
DrugBank ID DB05676
KEGG ID D08860
MeSH ID C505730
PubChem ID 10151715
NDC Product Code 65977-0119; 60219-1410; 60219-1744; 66406-0240; 66039-934; 70518-3155; 12658-0581; 69766-024; 59572-630; 65372-1204; 59572-631; 55513-369; 58032-2030; 59572-632; 53747-077; 55513-137; 59651-150; 53069-1040; 69766-010; 55513-485; 47621-306; 11722-062; 66406-0241; 46708-902; 65129-1383; 55111-993; 53069-1050; 73309-043; 49187-0757; 66406-0242
Synonyms apremilast | Otezla | CC 10004 | CC10004 | CC-10004
Chemical Information
Molecular Formula C22H24N2O7S
CAS Registry Number 253168-86-4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cerebral ischaemia24.04.06.003;
Cerebrovascular accident24.03.05.001;
Cervix carcinoma16.12.01.001; Available
Change of bowel habit07.02.03.0020.003474%Not Available
Chest discomfort22.02.08.001;; Available
Chest pain22.02.08.003;; Available
Chloasma23.05.01.001; Available
Choking22.02.05.001--Not Available
Cholangitis09.02.01.002--Not Available
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.001--Not Available
Chronic lymphocytic leukaemia16.01.06.001; Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Circulatory collapse24.06.02.001--Not Available
Cirrhosis alcoholic09.01.04.0050.000302%Not Available
Claustrophobia19.06.03.0050.001158%Not Available
Clavicle fracture15.08.03.010; Available
Clostridium difficile colitis11.02.02.004; Available
Coccidioidomycosis22.07.08.004; Available
Cold sweat23.02.03.002; Available
Colitis ulcerative07.08.01.005; Available
Colon cancer16.13.01.001; Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; Available
Concussion17.11.01.004; Available
Confusional state19.13.01.001;
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