Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apremilast
Drug ID BADD_D00156
Description Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene.[L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and central nervous system inflammation.[A181216]
Indications and Usage Investigated for use/treatment in psoriasis and psoriatic disorders.
Marketing Status Prescription
ATC Code L04AA32
DrugBank ID DB05676
KEGG ID D08860
MeSH ID C505730
PubChem ID 10151715
TTD Drug ID D07ESC
NDC Product Code 65977-0119; 60219-1410; 60219-1744; 66406-0240; 66039-934; 70518-3155; 12658-0581; 69766-024; 59572-630; 65372-1204; 59572-631; 55513-369; 58032-2030; 59572-632; 53747-077; 55513-137; 59651-150; 53069-1040; 69766-010; 55513-485; 47621-306; 11722-062; 66406-0241; 46708-902; 65129-1383; 55111-993; 53069-1050; 73309-043; 49187-0757; 66406-0242
Synonyms apremilast | Otezla | CC 10004 | CC10004 | CC-10004
Chemical Information
Molecular Formula C22H24N2O7S
CAS Registry Number 253168-86-4
SMILES CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gingival disorder07.09.03.001--Not Available
Gingival pain07.09.04.0010.005790%
Gingival recession07.09.03.0070.001158%Not Available
Gingival swelling07.05.04.003--Not Available
Gingivitis11.01.04.013; 07.09.03.003--
Glaucoma06.03.01.002--
Glomerular filtration rate decreased13.13.01.009--Not Available
Glossodynia07.14.02.001--Not Available
Glycosuria20.02.01.005--
Glycosylated haemoglobin increased13.02.02.005--Not Available
Goitre14.11.01.008; 05.02.01.001--Not Available
Gout14.09.01.001; 15.01.06.0010.027213%Not Available
Granuloma annulare23.03.15.0050.001158%Not Available
Groin pain15.03.02.004--Not Available
Guillain-Barre syndrome17.09.01.001; 11.07.01.001; 10.04.10.005--
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematochezia07.12.02.003; 24.07.02.012--Not Available
Haematocrit decreased13.01.05.001--Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006--
Blood urine present13.13.02.002--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Haemoptysis02.01.02.006; 24.07.01.006; 22.02.03.004--Not Available
Haemorrhagic stroke24.07.04.014; 17.08.01.011--Not Available
Haemorrhoids24.10.02.002; 07.15.03.001--
Hair colour changes23.02.06.001--
Hair growth abnormal23.02.06.0060.005790%Not Available
Hair texture abnormal23.02.06.004--
Hallucination19.10.02.002--
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