Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine hydrochloride
Drug ID BADD_D00153
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Marketing Status Prescription; Discontinued
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D02004
MeSH ID D001058
PubChem ID 9410
TTD Drug ID D0H6QU
NDC Product Code 63402-015; 63402-120; 63402-115; 63402-010; 63402-188; 63402-020; 63402-130; 49452-0700; 38779-1764; 52817-720; 63402-125; 63402-088; 27505-004; 62991-1513; 52465-104; 52465-105; 63402-030; 63402-025; 12707-031; 51927-2303; 50396-6009; 63402-110
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H18ClNO2
CAS Registry Number 314-19-2
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionProtein c-FosP01100T28025Not Available
Tremor (excl congenital)Fatty acid-binding protein, adipocyteQ9R290Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Cardiac failure congestive02.05.01.002--Not Available
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chorea17.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Dehydration14.05.05.001--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Fall12.01.08.002--
Fatigue08.01.01.002--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia17.15.03.002; 19.02.01.002--
Libido increased21.03.02.007; 19.08.03.002--
Nausea07.01.07.001--
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Pain in extremity15.03.04.010--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
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