Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine
Drug ID BADD_D00152
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Marketing Status Prescription; Discontinued
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D07460
MeSH ID D001058
PubChem ID 6005
TTD Drug ID D0H6QU
NDC Product Code Not Available
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H17NO2
CAS Registry Number 58-00-4
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionProtein c-FosP01100T2802511070194; 1347413; 7477877
Tremor (excl congenital)Fatty acid-binding protein, adipocyteQ9R290Not Available25933950
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sleep disorder19.02.04.0010.001273%Not Available
Sneezing22.02.05.0110.000849%
Somnolence19.02.05.003; 17.02.04.0060.006791%
Swelling08.01.03.015--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.0080.001273%
Tremor17.01.06.0020.002122%
Unresponsive to stimuli17.02.05.0310.000849%Not Available
Urinary tract infection20.08.02.001; 11.01.14.0040.001698%
Vomiting07.01.07.0030.005518%
Weight decreased13.15.01.0050.001273%
Yawning22.02.05.0170.002547%Not Available
Contusion24.07.06.001; 23.03.11.002; 15.03.01.008; 12.01.06.001--
Musculoskeletal discomfort15.03.04.001--Not Available
Nodule08.03.05.0020.004245%Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Hot flush21.02.02.001; 08.01.03.027; 24.03.01.0050.000849%
Cardiac disorder02.01.01.0030.000221%Not Available
Inflammation08.01.05.0070.000849%Not Available
Mental disorder19.07.01.002--Not Available
Upper limb fracture15.08.03.018; 12.04.01.0180.000849%Not Available
Parkinson's disease17.01.05.0100.000443%Not Available
Disease progression08.01.03.0380.000332%
Psychotic disorder19.03.01.002--
Hypersexuality19.08.03.005--Not Available
Skin mass23.07.04.0140.001273%Not Available
Autoimmune haemolytic anaemia01.06.01.004; 10.04.01.0050.000849%Not Available
Gambling disorder19.07.02.014--Not Available
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