Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal fistula07.11.05.0010.000043%
Gastrointestinal carcinoma16.13.04.001; 07.21.03.0010.000260%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.028353%Not Available
Gastrointestinal necrosis24.04.08.006; 07.15.01.0030.000087%
Gingival bleeding24.07.02.010; 07.09.07.0010.002352%Not Available
Gingival pain07.09.13.010--
Glossitis07.14.01.001--Not Available
Glossodynia07.14.02.001--Not Available
Goitre14.11.01.008; 05.02.01.0010.000139%Not Available
Gout15.01.06.001; 14.09.01.0010.001050%Not Available
Groin pain15.03.02.0040.000204%Not Available
Haemangioma24.03.06.004; 16.02.01.0020.000087%Not Available
Haemarthrosis24.07.01.046; 15.01.01.004; 12.04.03.0010.001341%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.002382%Not Available
Haematochezia07.12.02.003; 24.07.02.0120.003623%Not Available
Haematoma24.07.01.0010.011077%
Haematospermia24.07.03.008; 21.03.03.0030.000295%Not Available
Haematuria24.07.01.047; 20.02.01.006; 21.10.01.0180.013988%
Blood urine present13.13.02.002--Not Available
Haemoglobin13.01.05.018--Not Available
Haemolytic uraemic syndrome20.01.03.011; 01.06.02.0010.000108%
Haemoptysis02.11.04.009; 24.07.01.006; 22.02.03.0040.004651%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.0080.013142%
Haemorrhage subcutaneous24.07.06.010; 23.06.07.0020.001406%Not Available
Haemorrhagic disorder24.07.01.021; 01.01.03.0040.000434%Not Available
Haemorrhagic stroke24.07.04.014; 17.08.01.0110.002929%Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.001479%
Haemothorax22.05.02.001; 12.01.18.005; 24.07.01.0080.000911%
Hemianopia17.17.01.012; 06.02.07.0040.000087%Not Available
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