Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Carotid artery stenosis24.04.06.001; 17.08.02.0010.001325%Not Available
Carotid artery thrombosis24.01.04.007; 17.08.01.0250.000530%Not Available
Carpal tunnel syndrome17.09.02.0010.002252%Not Available
Cataract06.06.01.0010.008479%
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebellar infarction24.04.06.007; 17.08.01.0130.001457%Not Available
Cerebral artery embolism17.08.01.001; 24.01.04.0010.001106%Not Available
Cerebral artery occlusion24.04.06.020; 17.08.01.0280.001060%Not Available
Cerebral atrophy17.11.01.001--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.016277%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.049282%Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.0050.001590%
Cerebral thrombosis24.01.04.003; 17.08.01.0060.001457%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.153144%
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000380%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.001--Not Available
Cholangitis09.02.01.0020.001060%Not Available
Cholecystitis09.03.01.0010.001855%
Cholecystitis acute09.03.01.003--Not Available
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.001--Not Available
Chromaturia20.02.01.0020.003312%
Chronic lymphocytic leukaemia16.01.06.001; 01.10.06.001--Not Available
Chronic myeloid leukaemia16.01.07.001; 01.10.07.001--Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Chronic sinusitis22.07.03.018; 11.01.13.0160.000265%Not Available
Circulatory collapse24.06.02.001--Not Available
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