Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ear disorder04.03.01.0010.000087%Not Available
Ear haemorrhage12.01.14.004; 24.07.01.004; 04.03.01.0020.000399%Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.0010.001636%Not Available
Embolic stroke24.01.04.010; 17.08.01.0320.003189%Not Available
Embolism arterial24.01.01.0140.000195%
Embolism venous24.01.01.0030.001323%Not Available
Emphysema22.01.02.0020.000152%Not Available
Endometrial cancer21.07.02.002; 16.12.02.0010.000087%Not Available
Epidural anaesthesia25.01.03.004--Not Available
Epistaxis24.07.01.005; 22.04.03.0010.019984%
Erythropenia01.07.02.0010.000043%Not Available
Essential thrombocythaemia16.21.03.004; 01.13.03.0030.000043%Not Available
Exophthalmos06.09.04.001; 05.02.02.0020.000043%Not Available
Eye disorder06.08.03.0010.000911%Not Available
Eye haemorrhage12.02.02.012; 24.07.05.002; 06.07.02.0010.001345%Not Available
Eyelid ptosis06.05.01.002; 17.17.02.0040.000226%Not Available
Facial paralysis17.04.03.0080.000564%Not Available
Faeces discoloured07.01.03.0020.002260%Not Available
Faeces hard07.01.03.0030.000117%Not Available
Flank pain08.01.08.007; 20.02.03.006; 15.03.04.0030.000477%
Gallbladder cancer16.07.05.001; 09.04.02.0050.000043%Not Available
Gamma-glutamyltransferase increased13.03.04.024--
Gastric cancer16.13.03.001; 07.21.02.0010.000759%Not Available
Gastric haemorrhage24.07.02.007; 07.12.01.0010.005632%
Gastric polyps16.05.03.001; 07.20.01.0030.000139%Not Available
Gastric ulcer07.04.03.0020.001410%
Gastric ulcer haemorrhage24.07.02.003; 07.04.03.0050.000573%Not Available
Gastritis07.08.02.0010.000994%
Gastritis erosive07.04.03.0030.000412%Not Available
Gastritis haemorrhagic07.08.02.002; 24.07.02.0080.000217%Not Available
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