Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
International normalised ratio fluctuation13.01.02.0530.001192%Not Available
Thyroid haemorrhage24.07.01.083; 05.02.01.0050.000530%Not Available
Breast haematoma24.07.03.020; 21.05.05.0130.000662%Not Available
Age-related macular degeneration06.09.03.0180.000795%Not Available
Tooth socket haemorrhage24.07.02.059; 07.09.05.0170.000397%Not Available
Thalamic infarction17.08.01.061; 24.04.06.0410.000138%Not Available
Eyelid haematoma24.07.05.013; 23.06.07.007; 12.01.04.025; 06.07.05.0020.000265%Not Available
Ligament rupture12.01.07.014; 15.07.02.0080.000265%Not Available
Gastric fistula12.02.03.018; 07.11.05.0110.001192%
Stress cardiomyopathy24.04.04.026; 02.04.01.012--Not Available
Post procedural stroke24.04.06.039; 17.08.01.057; 12.02.04.0100.000173%Not Available
Myocardial strain13.14.02.0190.000397%Not Available
Basal ganglia haemorrhage24.07.04.021; 17.08.01.0390.000553%Not Available
Vasogenic cerebral oedema17.07.02.0080.000265%Not Available
Cerebral microhaemorrhage17.08.02.019; 24.07.04.0250.000397%Not Available
Abdominal wall haematoma24.07.02.039; 07.16.05.0050.002517%Not Available
Haemorrhagic hepatic cyst09.01.08.013; 24.07.01.070; 16.06.02.0030.000397%Not Available
Cerebral amyloid angiopathy17.08.02.017; 10.02.05.003; 24.03.05.0100.000173%Not Available
Capillaritis24.05.02.017; 23.06.02.0070.000265%Not Available
Cerebellar ischaemia24.04.06.033; 17.08.01.0470.000265%Not Available
Brain midline shift17.11.01.0110.001722%Not Available
Clostridium test positive13.08.01.0070.000265%Not Available
Streptococcus test positive13.08.01.0160.000795%Not Available
Helicobacter test positive13.08.01.0100.000530%Not Available
Gastrointestinal vascular malformation24.03.03.031; 07.15.04.0070.000397%Not Available
Seizure like phenomena17.12.03.0300.000397%Not Available
Periorbital haemorrhage24.07.05.015; 23.03.11.021; 12.01.04.027; 06.07.02.0080.000265%Not Available
Infectious pleural effusion22.05.01.004; 11.01.09.0110.000069%Not Available
Vertebral artery dissection24.02.04.006; 17.08.06.0040.000265%Not Available
Spinal pain08.01.08.030; 17.10.01.020; 15.02.01.008--Not Available
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