Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Diabetic foot17.09.04.006; 14.07.06.001; 05.07.06.001; 24.04.03.015; 23.07.03.0080.000087%Not Available
Embolic cerebral infarction24.01.04.009; 17.08.01.0290.000260%Not Available
Appendix disorder07.11.01.0200.000108%Not Available
Arterial haemorrhage24.07.01.0630.000377%Not Available
Arterial stenosis24.04.02.0120.000043%Not Available
Cerebellar haematoma24.07.04.022; 17.08.01.0450.000174%Not Available
Malignant peritoneal neoplasm16.13.04.005; 07.21.03.0050.000043%Not Available
Tricuspid valve disease02.07.05.0040.000043%
Aortic valve disease02.07.03.0020.000412%
Angiodysplasia24.03.03.0170.000065%Not Available
Carotid artery disease24.03.05.009; 17.08.02.0160.000174%Not Available
Salivary gland cancer16.13.12.001; 07.21.07.0080.000043%Not Available
Erosive duodenitis07.04.02.0060.000108%Not Available
Endocarditis noninfective02.09.01.0030.000087%Not Available
Bladder tamponade20.02.02.024; 24.07.01.0640.000087%Not Available
Thoracic haemorrhage24.07.01.082; 22.02.07.0170.000130%Not Available
Chronic left ventricular failure02.05.02.0060.000117%Not Available
Microscopic polyangiitis20.05.01.017; 10.02.02.025; 24.12.04.0160.000065%Not Available
Pruritus allergic23.03.12.010; 10.01.03.0460.000043%Not Available
Thyroid haemorrhage24.07.01.083; 05.02.01.0050.000087%Not Available
Breast haematoma24.07.03.020; 21.05.05.0130.000108%Not Available
Age-related macular degeneration06.09.03.0180.000130%Not Available
Tooth socket haemorrhage24.07.02.059; 07.09.05.0170.000139%Not Available
Thalamic infarction24.04.06.041; 17.08.01.0610.000152%Not Available
Gastric fistula12.02.03.018; 07.11.05.0110.000304%
Basal ganglia haemorrhage24.07.04.021; 17.08.01.0390.000542%Not Available
Carotid arteriosclerosis24.04.06.031; 17.08.02.0150.000043%Not Available
Vasogenic cerebral oedema17.07.02.0080.000043%Not Available
Cerebral microhaemorrhage24.07.04.025; 17.08.02.0190.000087%Not Available
Abdominal wall haematoma24.07.02.039; 07.16.05.0050.000625%Not Available
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