Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
IgA nephropathy20.05.01.016; 10.02.01.0630.000043%Not Available
Intracranial tumour haemorrhage24.07.04.028; 17.08.01.052; 16.32.03.0230.000130%Not Available
Jugular vein thrombosis24.01.02.0070.000130%Not Available
Lung carcinoma cell type unspecified stage IV22.08.01.019; 16.19.02.0060.000043%Not Available
Lymphadenopathy mediastinal22.09.03.006; 01.09.01.0250.000043%Not Available
Malignant pleural effusion22.05.04.001; 16.32.03.0140.000065%Not Available
Mesenteric arterial occlusion24.04.08.003; 07.15.02.0020.000065%Not Available
Metastases to adrenals16.22.02.012; 05.01.04.0070.000043%Not Available
Mitral valve stenosis02.07.01.0090.000174%Not Available
Myocardial fibrosis02.04.02.0160.000043%Not Available
Nephritis allergic20.05.01.018; 10.01.03.0440.000087%Not Available
Oesophageal ulcer haemorrhage24.07.02.051; 07.04.05.007--Not Available
Overweight14.03.02.0210.000234%Not Available
Pancreatic carcinoma metastatic16.13.10.003; 07.21.09.0060.000195%Not Available
Persecutory delusion19.10.01.0070.000108%Not Available
Prostatic haemorrhage24.07.03.028; 21.04.01.0090.000174%
Rectal adenocarcinoma07.21.05.005; 16.13.01.0160.000087%Not Available
Recurrent cancer16.16.01.0150.000130%Not Available
Renal haematoma24.07.07.004; 20.01.02.018; 12.01.05.0060.000195%Not Available
Ruptured cerebral aneurysm17.08.01.059; 24.02.04.0050.000152%Not Available
Senile dementia19.20.02.009; 17.03.01.0080.000065%Not Available
Splenic haematoma12.01.17.019; 24.07.01.079; 01.09.02.0140.000043%Not Available
Splenic haemorrhage12.01.17.020; 24.07.01.080; 01.09.02.0150.000217%Not Available
Starvation14.03.02.0250.000043%Not Available
Stasis dermatitis24.10.04.004; 23.03.04.0410.000043%Not Available
Urinary bladder haemorrhage24.07.01.086; 20.03.01.0230.001050%Not Available
Varicose vein ruptured24.10.04.0050.000043%Not Available
Aneurysm ruptured24.02.01.0020.000174%Not Available
Subdural hygroma17.11.01.0180.000087%Not Available
Atrial thrombosis02.11.01.002; 24.01.05.0050.003341%Not Available
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