Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bowel movement irregularity07.02.03.003--Not Available
Pyramidal tract syndrome17.05.05.0030.000043%
Cerebral artery stenosis24.04.06.023; 17.08.02.0100.000065%Not Available
Erosive oesophagitis07.04.05.0040.000087%Not Available
Vascular stent thrombosis08.07.05.002; 24.01.01.0440.000195%Not Available
Skin haemorrhage24.07.01.103; 23.06.07.0010.000482%Not Available
Spontaneous haematoma24.07.01.054; 01.01.03.0060.000560%Not Available
Aortic arteriosclerosis24.04.01.0040.000043%Not Available
Loose tooth07.09.05.0090.000139%Not Available
Bronchial haemorrhage22.03.02.007; 24.07.01.0450.000043%Not Available
Laryngeal haemorrhage24.07.01.051; 22.04.01.005; 12.01.09.009--
Vessel puncture site haematoma24.07.01.018; 12.07.04.003; 08.02.04.0020.000043%Not Available
Sphincter of Oddi dysfunction09.02.02.004; 07.18.02.0020.000065%Not Available
Treatment failure08.06.01.0170.002616%Not Available
Regurgitation07.01.07.0040.000043%Not Available
Haemorrhagic erosive gastritis24.07.02.037; 07.04.03.0080.000043%Not Available
Abdominal wall haemorrhage12.01.17.002; 24.07.02.036; 07.16.05.0020.000087%Not Available
Neurological decompensation17.02.05.0300.000108%Not Available
Acute kidney injury20.01.03.016--
Procedural haemorrhage24.07.01.053; 12.02.05.036--
Central nervous system haemorrhage24.07.04.016; 17.08.01.0350.000108%Not Available
Peripheral artery thrombosis24.01.02.0100.000260%Not Available
Application site haemorrhage24.07.01.048; 12.07.01.040; 08.02.01.040--Not Available
Microembolism24.01.01.0250.000087%Not Available
Autoimmune haemolytic anaemia01.06.01.004; 10.04.01.0050.000174%Not Available
Peripheral venous disease24.04.02.0220.000291%Not Available
Sinus node dysfunction02.03.03.0170.000174%
Spinal cord haematoma17.08.01.037; 12.01.13.005; 24.07.04.0190.000174%Not Available
Perforation08.01.03.0580.000065%Not Available
Stenosis08.01.03.0600.000065%Not Available
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