Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Varices oesophageal24.10.02.004; 09.01.06.009; 07.15.05.0010.000152%Not Available
Intra-abdominal haematoma24.07.02.034; 07.12.02.0050.000174%Not Available
Gaze palsy17.02.05.044; 06.05.02.0140.000065%Not Available
Gastrointestinal ulcer haemorrhage24.07.02.023; 07.04.04.0060.000334%Not Available
Palpable purpura24.12.04.018; 23.06.02.006; 10.02.02.0190.000161%Not Available
Rectal tenesmus15.05.03.011; 07.03.03.0010.000095%Not Available
Urine odour abnormal20.02.01.0200.000265%Not Available
Peripheral artery aneurysm24.02.05.0010.000043%Not Available
Ocular retrobulbar haemorrhage06.07.02.003; 12.01.04.035; 24.07.05.0070.000043%Not Available
Cognitive disorder17.03.03.003; 19.21.02.001--
Bloody discharge24.07.01.041; 08.01.03.0390.000065%Not Available
Dysplasia08.03.04.0070.000108%Not Available
Retroperitoneal haematoma24.07.01.060; 07.07.02.0050.000564%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.001258%Not Available
Aortic disorder24.03.04.0040.000087%Not Available
Thyroid mass05.02.01.0030.000065%Not Available
Haemobilia24.07.01.049; 09.01.08.0090.000217%Not Available
Venous occlusion24.04.02.0090.000065%Not Available
Intestinal mass07.11.01.0100.000043%Not Available
Blue toe syndrome24.01.02.004; 12.02.01.0050.000139%Not Available
Intestinal haemorrhage24.07.02.031; 07.12.03.0050.000456%Not Available
Incision site haematoma24.07.01.050; 12.02.05.034--Not Available
Angiopathy24.03.02.0070.000304%Not Available
Extremity necrosis24.04.03.0120.000065%Not Available
Blood alkaline phosphatase increased13.04.02.004--
Ischaemic cerebral infarction24.04.06.013; 17.08.01.0220.000260%Not Available
Post lumbar puncture syndrome17.14.01.012; 12.02.04.004--Not Available
Aortic rupture24.03.04.009; 12.01.11.0070.000043%Not Available
Abdominal neoplasm16.16.02.002; 07.21.04.0010.000043%Not Available
Adverse event08.06.01.0100.036514%Not Available
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