Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vitreous haemorrhage24.07.05.005; 06.10.03.0010.000269%
Post thrombotic syndrome24.01.01.0190.000174%Not Available
Intestinal polyp16.05.01.002; 07.20.01.0090.000356%Not Available
Intracardiac thrombus02.11.01.017; 24.01.05.0030.000941%Not Available
Wound secretion12.01.08.007; 08.01.03.035--Not Available
Axillary pain08.01.08.0150.000095%Not Available
Underweight14.03.02.0170.000117%Not Available
Ischaemic cardiomyopathy24.04.04.019; 02.04.01.0040.000108%Not Available
Carotid artery occlusion24.04.06.008; 17.08.01.0120.000152%Not Available
Spinal cord haemorrhage24.07.04.010; 17.08.01.030; 12.01.13.0030.000542%Not Available
Weight fluctuation14.03.02.0020.000360%Not Available
Chapped lips07.05.01.004--Not Available
Oesophagitis ulcerative07.04.05.0030.000043%Not Available
Tachyarrhythmia02.03.02.0080.000195%Not Available
Anal haemorrhage24.07.02.029; 07.12.03.0040.000217%
Muscle fatigue15.05.03.006--Not Available
Urethral haemorrhage24.07.03.006; 20.07.01.0030.000247%Not Available
Tumour haemorrhage24.07.01.028; 16.32.03.0080.000824%
Pituitary haemorrhage24.07.04.009; 17.08.01.019; 05.03.04.0050.000065%Not Available
Shock haemorrhagic24.06.02.014; 14.05.05.0030.001931%Not Available
Dry gangrene24.04.03.018; 23.06.06.0030.000043%Not Available
Idiosyncratic drug reaction08.06.01.0020.000043%Not Available
Cervix haemorrhage uterine24.07.03.011; 21.06.01.005--Not Available
Urogenital haemorrhage24.07.01.044; 21.10.05.008; 20.08.01.0060.000195%Not Available
Spinal epidural haematoma12.01.13.006; 24.07.04.020; 17.08.01.0380.000152%Not Available
Carotid sinus syndrome24.03.04.002; 17.04.06.0010.000043%Not Available
Scleral haemorrhage06.07.01.002; 24.07.05.0090.000043%Not Available
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Lower gastrointestinal haemorrhage24.07.02.030; 07.12.03.0110.001809%
Deep vein thrombosis24.01.02.0030.017389%Not Available
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