Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haemolytic anaemia01.06.03.002--Not Available
Haemolytic uraemic syndrome20.01.03.011; 01.06.02.0010.000662%
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.0060.014440%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.0080.017003%
Haemorrhage subcutaneous23.06.07.002; 24.07.06.0100.006226%Not Available
Haemorrhagic disorder24.07.01.021; 01.01.03.0040.000662%Not Available
Haemorrhagic stroke24.07.04.014; 17.08.01.0110.003836%Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.005697%
Haemothorax24.07.01.008; 22.05.02.001; 12.01.03.0020.003179%
Hair texture abnormal23.02.06.004--
Hallucination19.10.02.002--
Hallucination, visual19.10.02.004--Not Available
Hand fracture15.08.03.014; 12.04.01.0140.000662%Not Available
Haptoglobin decreased13.02.03.0010.000265%
Head discomfort17.02.05.027--Not Available
Headache17.14.01.001--
Heart rate abnormal13.14.04.0060.000530%Not Available
Heart rate increased13.14.04.002--Not Available
Heart rate irregular13.14.04.003--Not Available
Hemianopia17.17.01.012; 06.02.07.0040.000530%Not Available
Hemiparesis17.01.04.0010.005167%
Hemiplegia17.01.04.0020.002650%Not Available
Henoch-Schonlein purpura24.07.06.003; 23.06.01.002; 10.02.02.004; 01.01.04.0010.000265%Not Available
Hepatic cirrhosis09.01.04.001--Not Available
Hepatic congestion09.01.05.008; 02.05.04.0130.000104%Not Available
Hepatic cyst16.06.02.001; 09.01.08.0080.000397%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.006--Not Available
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatic haemorrhage24.07.01.027; 12.01.02.007; 09.01.06.0080.000795%
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