Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.130225%Not Available
Gastrointestinal necrosis24.04.08.006; 07.15.01.0030.000138%
Gastrointestinal pain07.01.05.005--
Gastrointestinal perforation07.04.04.0010.000138%Not Available
Generalised oedema14.05.06.007; 08.01.07.004--
Generalised tonic-clonic seizure17.12.01.002--Not Available
Gingival bleeding24.07.02.010; 07.09.07.0010.006624%Not Available
Gingival swelling07.05.04.003--Not Available
Gingivitis07.09.03.003; 11.01.04.013--
Glaucoma06.03.01.002--
Glomerular filtration rate decreased13.13.01.0090.001457%Not Available
Glossodynia07.14.02.001--Not Available
Glycosylated haemoglobin increased13.02.02.005--Not Available
Goitre14.11.01.008; 05.02.01.0010.000397%Not Available
Gout15.01.06.001; 14.09.01.0010.002385%Not Available
Granulocyte count decreased13.01.06.0050.000265%Not Available
Groin pain15.03.02.0040.000795%Not Available
Haemangioma24.03.06.004; 16.02.01.0020.000530%Not Available
Haemarthrosis24.07.01.046; 15.01.01.004; 12.04.03.0010.005961%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.009671%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.015367%Not Available
Haematocrit decreased13.01.05.0010.003974%Not Available
Haematoma24.07.01.0010.037359%
Haematospermia24.07.03.008; 21.03.03.0030.000530%Not Available
Haematuria24.07.01.047; 20.02.01.0060.033252%
Blood urine present13.13.02.0020.010996%Not Available
Haemoglobin13.01.05.018--Not Available
Haemoglobin abnormal13.01.05.0110.000662%Not Available
Haemoglobin decreased13.01.05.0030.040803%Not Available
Haemoglobin increased13.01.05.004--
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