Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Anidulafungin
Drug ID BADD_D00143
Description Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366. There is preliminary evidence that it has a similar safety profile to caspofungin.
Indications and Usage For use in the treatment of the following fungal infections: Candidemia and other forms of Candida infections (intra-abdominal abscess, and peritonitis), Aspergillus infections, and esophageal candidiasis. Also considered an alternative treatment for oropharyngeal canaidiasis.
Marketing Status Prescription
ATC Code J02AX06
DrugBank ID DB00362
KEGG ID D03211
MeSH ID D000077612
PubChem ID 166548
TTD Drug ID D0F9BY
NDC Product Code 68254-0013; 0049-0116; 11722-054; 62227-007; 0009-0043; 0049-0114; 65727-072
Synonyms Anidulafungin | 1-((4R,5R)-4,5-Dihydroxy-N2-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-L-ornithine)-echinocandin B | LY 303366 | LY303366 | LY-303366 | Eraxis
Chemical Information
Molecular Formula C58H73N7O17
CAS Registry Number 166663-25-8
SMILES CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C( NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC=C(C=C7)O)O)O)C(C)O)C)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sinus arrhythmia02.03.03.008--Not Available
Skin disorder23.03.03.007--Not Available
Systemic candida11.03.03.016--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Thrombophlebitis superficial24.01.02.002--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Ventricular extrasystoles02.03.04.007--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
White blood cell count decreased13.01.06.012--
White blood cell count increased13.01.06.013--Not Available
Deep vein thrombosis24.01.02.003--Not Available
Platelet count increased13.01.04.002--Not Available
Infusion related reaction12.02.05.009; 10.01.01.017; 08.01.03.002--
Lymphatic disorder01.09.01.003--Not Available
Pruritus generalised23.03.12.003--Not Available
Infusion site pain12.07.05.002; 08.02.05.014--Not Available
Angiopathy24.03.02.007--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Hepatic enzyme increased13.03.01.019--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Cardiac disorder02.01.01.003--Not Available
Clostridial infection11.02.02.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
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