Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amphotericin b
Drug ID BADD_D00132
Description Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Indications and Usage Used to treat potentially life threatening fungal infections.
Marketing Status approved; investigational
ATC Code A01AB04; A07AA07; G01AA03; J02AA01
DrugBank ID DB00681
KEGG ID D00203
MeSH ID D000666
PubChem ID 14956
TTD Drug ID D02DWM
NDC Product Code 65044-7183; 62756-233; 38779-0191; 51552-0304; 51927-1726; 62991-1173; 39822-1055; 55500-0001; 63622-0123; 63622-0124; 63622-0125; 0469-3051; 39635-0003; 45932-0008; 55150-365
UNII 7XU7A7DROE
Synonyms Amphotericin B | Amphotericin | Fungizone | Amphotericin B Cholesterol Dispersion | Amphotericin B Colloidal Dispersion | Amphocil
Chemical Information
Molecular Formula C47H73NO17
CAS Registry Number 1397-89-3; 30652-87-0
SMILES CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O) O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nephrogenic diabetes insipidus20.05.03.010; 14.05.07.002--Not Available
Nephropathy toxic20.05.03.002; 12.03.01.0100.000517%Not Available
Nephrotic syndrome20.05.01.002--
Nervous system disorder17.02.10.0010.000094%Not Available
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neurosis19.06.01.001--Not Available
Normochromic normocytic anaemia01.03.02.005--Not Available
Oedema08.01.07.006; 14.05.06.0100.000188%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oliguria20.01.03.004--Not Available
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pancreatitis07.18.01.0010.000094%
Pancreatitis acute07.18.01.0020.000094%Not Available
Pancreatitis necrotising07.18.01.0040.000188%Not Available
Pancytopenia01.03.03.0030.000329%Not Available
Paraesthesia17.02.06.005; 23.03.03.094--
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Pharyngitis07.05.07.004; 22.07.03.004; 11.01.13.003--
Phlebitis12.02.01.002; 24.12.03.004--
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumothorax22.05.02.0030.000094%
Polyuria20.02.03.0020.000094%Not Available
Premature baby18.04.02.0010.000188%Not Available
Premature delivery18.07.01.0060.000141%
Prothrombin level decreased13.01.02.010--Not Available
The 8th Page    First    Pre   8 9 10 11 12    Next   Last    Total 13 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene