Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amphotericin b
Drug ID BADD_D00132
Description Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Indications and Usage Used to treat potentially life threatening fungal infections.
Marketing Status Prescription; Discontinued
ATC Code A01AB04; A07AA07; G01AA03; J02AA01
DrugBank ID DB00681
KEGG ID D00203
MeSH ID D000666
PubChem ID 14956
TTD Drug ID D02DWM
NDC Product Code 38779-0191; 63622-0125; 63622-0123; 65044-7183; 51552-0304; 51927-1726; 45932-0008; 55500-0001; 63622-0124; 62991-1173; 62756-233; 39822-1055; 0469-3051
Synonyms Amphotericin B | Amphotericin | Fungizone | Amphotericin B Cholesterol Dispersion | Amphotericin B Colloidal Dispersion | Amphocil
Chemical Information
Molecular Formula C47H73NO17
CAS Registry Number 1397-89-3
SMILES CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O) O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cell deathD-dopachrome decarboxylaseP30046Not AvailableNot Available
Cell deathMacrophage migration inhibitory factorP14174T39977Not Available
NeurotoxicityInterleukin-1 alphaP01583T16340Not Available
NeurotoxicityNitric oxide synthase, inducibleQ06518Not AvailableNot Available
NeurotoxicityInterferon gammaP01579T77664Not Available
NeurotoxicityNuclear factor NF-kappa-B p105 subunitP19838T40192Not Available
NeurotoxicityTumor necrosis factorP01375T20178Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aspartate aminotransferase increased13.03.01.0060.000412%
Asphyxia22.02.02.001; 12.01.08.0110.000108%Not Available
Aspiration22.02.07.0070.000108%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.002--
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.0050.001855%
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.0040.002267%
Blood fibrinogen increased13.01.02.004--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood potassium abnormal13.11.01.0240.000412%Not Available
Blood potassium decreased13.11.01.010--Not Available
Blood pressure systolic increased13.14.03.0060.000412%Not Available
Blood thromboplastin decreased13.01.02.005--Not Available
Blood triglycerides increased13.12.03.0010.000412%Not Available
Blood urea increased13.13.01.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.0020.000412%Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cardiac arrest02.03.04.0010.000161%
Cardiac failure02.05.01.0010.000108%
Cardiac failure congestive02.05.01.002--Not Available
Cardiomegaly02.04.02.001--Not Available
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