Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aminoglutethimide
Drug ID BADD_D00107
Description An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454)
Indications and Usage For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
Marketing Status Discontinued
ATC Code L02BG01
DrugBank ID DB00357
KEGG ID D00574
MeSH ID D000616
PubChem ID 2145
TTD Drug ID D0M6DO
NDC Product Code Not Available
Synonyms Aminoglutethimide | Cytadren | Orimeten
Chemical Information
Molecular Formula C13H16N2O2
CAS Registry Number 125-84-8
SMILES CCC1(CCC(=O)NC1=O)C2=CC=C(C=C2)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cardiovascular disorderAdenylate kinase isoenzyme 1P00568Not Available9456245; 10473018; 14623544; 10514021; 10388095; 9556789; 15814851; 14513432; 11850229; 14687601; 15083379
OsteoporosisAdenylate kinase isoenzyme 1P00568Not Available9456245; 10473018; 14623544; 10514021; 10388095; 9556789; 15814851; 14513432; 11850229; 14687601; 15083379
Urogenital disorderAdenylate kinase isoenzyme 1P00568Not Available9456245; 10473018; 14623544; 10514021; 10388095; 9556789; 15814851; 14513432; 11850229; 14687601; 15083379
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypothyroidism14.11.01.012; 05.02.03.001--
Leukopenia01.02.02.001--Not Available
Malaise08.01.01.003--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Pancytopenia01.03.03.003--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rhabdomyolysis15.05.05.002--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.010--
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Supraventricular tachycardia02.03.03.012--
Tachycardia02.03.02.007--Not Available
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Vascular resistance systemic13.14.03.019--Not Available
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
Virilism21.10.04.001; 05.05.01.001--
Vomiting07.01.07.003--
Excoriation23.03.11.003; 12.01.06.007--Not Available
Haemodynamic instability24.03.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Precocious puberty21.03.02.009; 05.05.03.001--
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