Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alogliptin benzoate
Drug ID BADD_D00080
Description Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Marketing Status Prescription
ATC Code A10BH04
DrugBank ID DB06203
KEGG ID D06553
MeSH ID C520853
PubChem ID 16088021
TTD Drug ID D0NJ5H
NDC Product Code 14445-016; 66039-924; 69037-0024; 14501-0024
Synonyms alogliptin | 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl) benzonitrile | nesina | SYR 322 | SYR322 | SYR-322
Chemical Information
Molecular Formula C25H27N5O4
CAS Registry Number 850649-62-6
SMILES CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N.C1=CC=C(C=C1)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AngioedemaCytochrome P450 3A4P08684T37848Not Available
AngioedemaCytochrome P450 2D6P10635T57392Not Available
HeadacheCytochrome P450 2D6P10635T57392Not Available
HeadacheCytochrome P450 3A4P08684T37848Not Available
HypoglycaemiaCytochrome P450 2D6P10635T57392Not Available
HypoglycaemiaCytochrome P450 3A4P08684T37848Not Available
NasopharyngitisCytochrome P450 3A4P08684T37848Not Available
NasopharyngitisCytochrome P450 2D6P10635T57392Not Available
Stevens-Johnson syndromeCytochrome P450 2D6P10635T57392Not Available
Stevens-Johnson syndromeCytochrome P450 3A4P08684T37848Not Available
Type IV hypersensitivity reactionCytochrome P450 3A4P08684T37848Not Available
Type IV hypersensitivity reactionCytochrome P450 2D6P10635T57392Not Available
Upper respiratory tract infectionCytochrome P450 2D6P10635T57392Not Available
Upper respiratory tract infectionCytochrome P450 3A4P08684T37848Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute hepatic failure09.01.03.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.002--Not Available
Rash23.03.13.001--Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urticaria23.04.02.001; 10.01.06.001--
Hepatic enzyme increased13.03.01.019--Not Available
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