Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Allopurinol
Drug ID BADD_D00076
Description Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints [A175942]. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals [A175942]. Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout [A36705]. It was initially approved by the FDA in 1966 [L5674] and is now formulated by several manufacturers [L5677].
Indications and Usage For the treatment of hyperuricemia associated with primary or secondary gout. Also indicated for the treatment of primary or secondary uric acid nephropathy, with or without the symptoms of gout, as well as chemotherapy-induced hyperuricemia and recurrent renal calculi.
Marketing Status Prescription; Discontinued
ATC Code M04AA01
DrugBank ID DB00437
KEGG ID D00224
MeSH ID D000493
PubChem ID 135401907
TTD Drug ID D04KYY
NDC Product Code 50268-063; 49711-0113; 16714-041; 0603-2116; 14445-001; 69967-008; 55700-879; 50090-4662; 23155-694; 53489-156; 0591-5544; 0904-7041; 0378-0181; 55700-935; 66267-665; 61919-748; 50090-5194; 67457-187; 51079-206; 63739-796; 43063-976; 68083-380; 23155-693; 70518-1678; 71335-0112; 17351-0041; 55700-540; 67296-1265; 71610-253; 63629-2113; 51079-205; 50268-064; 29300-350; 68071-2660; 70934-072; 55700-947; 55154-5534; 50090-0044; 70934-389; 61919-471; 55111-730; 68071-1805; 71610-197; 70518-3289; 70710-1210; 63629-1781; 58118-1156; 67296-1314; 49452-0008; 70518-1806; 65015-606; 16729-135; 0904-6571; 63552-151; 70771-1127; 55154-2338; 62584-988; 70199-016; 70710-1209; 43353-088; 55154-7892; 16729-134; 0615-8385; 0591-5543; 68108-0212; 71205-208; 63629-8020; 43063-975; 71335-0467; 70771-1126; 68071-2616; 63187-240; 53002-4821; 36974-0018; 50090-2544; 69967-009; 70934-504; 63629-7908; 0615-8321; 51927-0070; 71610-064; 63629-2111; 50090-5168; 71610-194; 60760-134; 53002-4820; 65219-380; 70934-295; 65977-0124; 43063-793; 70199-015; 67457-978; 71610-231; 67544-736; 50090-3760; 43063-079; 71205-377; 62584-713; 71205-049; 50090-4663; 63629-1675; 63552-150; 0378-0137; 16714-042; 16714-577; 55154-7981; 16714-576; 43063-935; 29300-349; 70934-209; 70518-0451; 55289-010; 43353-186; 0603-2115; 55154-5454; 43063-774; 71335-1656; 55111-729; 60760-139; 0904-6572; 63629-2112; 70934-681; 43063-934; 50090-3758; 63739-410; 57451-1166; 60429-180; 66064-2100; 51927-1915; 66267-224; 68788-7542; 53489-157; 63187-463; 70518-1573; 68788-7383
Synonyms Allopurinol | Uribenz | Allopurin | Allorin | Allpargin | Allural | Pan Quimica | Apulonga | Apurin | Atisuril | Bleminol | Caplenal | Capurate | Cellidrin | Embarin | Suspendol | Foligan | Hamarin | Lopurin | Lysuron | Jenapurinol | Milurit | Milurite | Novopurol | Uripurinol | Urosin | Urtias | Xanthomax | Uridocid | Xanturic | Zygout | Zyloprim | Zyloric | Pureduct | Purinol | Progout | Remid | Rimapurinol | Roucol | Tipuric | Allohexal | Allohexan | Alloprin
Chemical Information
Molecular Formula C5H4N4O
CAS Registry Number 315-30-0
SMILES C1=NNC2=C1C(=O)NC=N2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Aplasia pure red cellGlycophorin-AP02724Not Available10398315; 16076905; 11816258
Reperfusion injuryMyeloperoxidaseP05164T2347114614706; 9583490; 9744646
Reperfusion injuryIntercellular adhesion molecule 1P05362T2620314614706; 9583490; 9744646
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haemoglobin decreased13.01.05.003--Not Available
Haemolysis01.06.04.0020.000132%
Haemolytic anaemia01.06.03.0020.000461%Not Available
Haemoptysis02.01.02.006; 24.07.01.006; 22.02.03.0040.000329%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Haemorrhage subcutaneous24.07.06.010; 23.06.07.0020.000132%Not Available
Haemorrhagic stroke24.07.04.014; 17.08.01.0110.000103%Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.000198%
Hallucination19.10.02.002--
Hallucination, visual19.10.02.0040.000198%Not Available
Headache17.14.01.001--
Heart rate increased13.14.04.002--Not Available
Hemianopia17.17.01.012; 06.02.07.0040.000132%Not Available
Hemiparesis17.01.04.001--
Hemiplegia17.01.04.0020.000132%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.000264%Not Available
Hepatic failure09.01.03.0020.000155%
Hepatic function abnormal09.01.02.0010.001054%Not Available
Hepatic necrosis09.01.07.0020.000198%
Hepatic steatosis14.08.04.005; 09.01.07.0030.000527%Not Available
Hepatitis09.01.07.0040.001647%Not Available
Hepatitis acute09.01.07.0050.000461%Not Available
Hepatitis cholestatic09.01.01.0020.000132%Not Available
Hepatitis toxic12.03.01.016; 09.01.07.0170.000132%Not Available
Hepatocellular injury09.01.07.0080.001516%Not Available
Hepatomegaly09.01.05.0010.000329%Not Available
Hepatosplenomegaly09.01.05.002; 01.09.03.0010.000264%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.000329%Not Available
Hernia08.01.04.0010.000132%Not Available
Herpes simplex23.09.03.001; 11.05.02.0010.000395%Not Available
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