Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Claustrophobia19.06.03.0050.000202%Not Available
Clavicle fracture15.08.03.010; 12.04.01.0100.000909%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.001212%Not Available
Coagulopathy01.01.02.0010.000404%Not Available
Coccydynia15.02.01.0040.000505%Not Available
Colitis07.08.01.0010.001010%
Colitis ischaemic24.04.08.012; 07.08.01.0040.000303%Not Available
Colitis ulcerative10.02.01.004; 07.08.01.0050.000606%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.000132%Not Available
Coma17.02.09.001--Not Available
Complex partial seizures17.12.02.0030.000202%Not Available
Compression fracture15.08.02.004; 12.04.02.0080.002122%Not Available
Concussion17.11.01.004; 12.01.10.0050.000606%Not Available
Conduction disorder02.03.01.0080.000303%
Confusional state17.02.03.005; 19.13.01.001--
Conjunctival haemorrhage24.07.05.001; 06.07.01.0010.000202%Not Available
Conjunctivitis11.01.06.012; 06.04.01.0020.001111%
Conjunctivitis allergic10.01.04.002; 06.04.01.0030.000505%Not Available
Constipation07.02.02.0010.010508%
Corneal abrasion12.01.04.001; 06.11.03.0010.000202%Not Available
Corneal dystrophy03.01.06.001; 06.13.03.0010.000202%Not Available
Coronary artery disease24.04.04.006; 02.02.01.0010.007578%Not Available
Costochondritis15.07.03.0010.000303%Not Available
Cough22.02.03.0010.005961%
Crohn's disease07.08.01.015; 10.02.01.0050.000505%Not Available
Crying17.02.05.013; 19.04.02.002; 12.02.11.001; 08.01.03.005--Not Available
Cushing's syndrome19.07.03.002; 14.11.01.007; 05.01.01.001; 24.08.04.0010.000303%Not Available
Cutis laxa23.03.02.009; 15.06.01.0070.000303%Not Available
Cyst16.02.02.002; 08.03.05.0010.003637%Not Available
Cystitis20.03.02.002; 11.01.14.0010.002324%
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