Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukoplakia23.01.06.002; 08.01.06.0130.000044%Not Available
Lung neoplasm16.19.04.001; 22.08.01.0060.000308%Not Available
Hyperlipidaemia14.08.03.0010.004755%
Knee deformity15.10.03.0020.000330%Not Available
Renal mass20.01.02.0070.000110%Not Available
Nasal disorder22.04.03.0040.000154%Not Available
Sinus disorder22.04.06.0020.000770%
Non-cardiac chest pain22.12.02.009; 08.01.08.0060.000088%
Poor quality sleep17.15.04.002; 19.02.05.0050.000308%Not Available
Middle ear effusion04.05.03.0010.000044%Not Available
Peripheral arterial occlusive disease24.04.03.0100.000242%Not Available
Effusion08.01.03.0520.000044%Not Available
Allergic respiratory symptom22.12.02.001; 10.01.03.0270.000066%Not Available
Erosive oesophagitis07.04.05.0040.000110%Not Available
Orthostatic intolerance02.11.01.019; 24.06.01.003; 17.05.01.0070.000044%Not Available
Lichenoid keratosis23.01.01.0040.000044%Not Available
Gastrointestinal inflammation07.08.03.0070.000044%Not Available
Pelvic discomfort21.10.01.012; 20.02.03.012; 07.01.06.0200.000044%Not Available
Complex regional pain syndrome17.02.07.010; 12.01.12.0040.000110%Not Available
Osteonecrosis of jaw15.02.04.010; 24.04.05.0050.010205%
Chronic kidney disease20.01.03.0170.000925%
Joint instability15.01.08.0070.000242%Not Available
Ulcerative keratitis10.02.01.021; 06.04.02.0040.000044%
Aortic arteriosclerosis24.04.01.0040.000418%Not Available
Cerebral arteriosclerosis24.04.06.019; 17.08.02.0080.000044%Not Available
Loose tooth07.09.05.0090.000581%Not Available
Bone loss15.02.04.0200.001017%Not Available
Central obesity14.03.02.0110.000044%Not Available
Bronchial hyperreactivity22.03.01.0160.000154%Not Available
Thyroid cancer16.24.03.001; 05.02.05.0010.000088%Not Available
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