Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Peripheral embolism24.01.02.0050.000066%Not Available
Spinal disorder15.02.04.0230.000933%Not Available
Spondylitis15.01.09.0020.000264%Not Available
Vaginal disorder21.08.01.0050.000088%Not Available
Cardiac valve disease02.07.02.0010.000154%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Corneal disorder06.08.01.0040.000044%Not Available
Ill-defined disorder08.01.03.049--Not Available
Intervertebral disc disorder15.10.01.0030.000484%Not Available
Lip and/or oral cavity cancer16.13.07.001; 07.21.07.0010.000044%Not Available
Inner ear disorder04.04.02.0020.000066%Not Available
Polyp16.02.02.005; 08.01.06.0100.000308%Not Available
Mitral valve disease02.07.01.0030.000176%
Ovarian neoplasm16.12.06.001; 21.11.01.0050.000044%Not Available
Parkinson's disease17.01.05.0100.000286%Not Available
Sensation of foreign body08.01.09.0020.000066%Not Available
Urinary tract obstruction20.08.01.0040.000088%
Ulcer haemorrhage08.03.06.003; 24.07.01.0400.000097%Not Available
Blood disorder01.05.01.0040.000264%Not Available
Immunodeficiency10.03.02.0020.000044%Not Available
Adverse drug reaction08.06.01.0090.001616%Not Available
Autoimmune disorder10.04.04.0030.000088%
Bone lesion15.02.04.0160.000317%Not Available
Bone marrow disorder01.05.01.0060.000088%Not Available
Chondrocalcinosis14.04.01.017; 15.01.06.0060.000396%Not Available
Chondropathy15.07.03.0030.000110%Not Available
Diverticular perforation07.04.04.0080.000044%Not Available
Drug intolerance08.06.01.0130.001378%Not Available
Obstructive airways disorder22.03.01.0110.000088%Not Available
Hepatic lesion09.01.08.0050.000044%Not Available
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