Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bone metabolism disorder15.02.03.009; 14.04.04.0090.000198%Not Available
Angiopathy24.03.02.0070.000440%Not Available
Anogenital warts07.19.04.002; 23.10.01.003; 21.10.03.004; 16.26.01.003; 11.05.07.0020.000044%Not Available
Extremity necrosis24.04.03.0120.000132%Not Available
Radicular pain17.10.01.0130.000132%Not Available
Adhesion08.01.03.0480.000066%Not Available
Induration08.01.03.0200.000066%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.000242%
Adverse event08.06.01.0100.007841%Not Available
Abdominal hernia07.16.06.0050.000132%Not Available
Benign neoplasm16.02.02.0070.000154%Not Available
Bladder disorder20.03.01.0020.000396%Not Available
Brain neoplasm17.20.01.003; 16.30.01.0030.000044%Not Available
Breast disorder21.05.04.0040.000286%Not Available
Cardiac disorder02.11.01.0030.000947%Not Available
Connective tissue disorder15.06.01.006; 10.04.04.0260.000110%Not Available
Eyelid disorder23.03.03.028; 06.08.03.0100.000088%Not Available
Embolism24.01.01.0090.000066%
Gastrointestinal motility disorder07.02.03.0010.000044%Not Available
Inflammation10.02.01.089; 08.01.05.0070.000383%Not Available
Limb discomfort15.03.04.0140.000198%Not Available
Intervertebral disc degeneration15.10.01.0020.002730%Not Available
Ischaemia24.04.02.0040.000088%Not Available
Jaw disorder15.02.04.0090.001184%Not Available
Malnutrition14.03.02.0040.000220%Not Available
Mental disorder19.07.01.0020.000660%Not Available
Metastatic neoplasm16.16.01.0070.000088%Not Available
Oesophageal disorder07.11.02.0010.000409%Not Available
Optic nerve disorder17.04.05.004; 06.02.08.0010.000044%
Oral neoplasm16.13.09.002; 07.21.08.0020.000044%Not Available
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