Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tendon disorder12.01.07.019; 15.07.01.0020.000440%Not Available
Tendonitis15.07.01.003; 12.01.07.0070.001360%Not Available
Tenosynovitis15.07.01.0040.000242%Not Available
Tension headache17.14.01.004; 19.24.01.0090.000132%Not Available
Throat irritation22.12.03.029; 07.05.05.0370.000260%Not Available
Throat tightness22.12.03.031; 19.01.02.005--Not Available
Thrombocytosis01.08.02.0010.000088%Not Available
Thrombotic microangiopathy24.01.01.013; 20.01.07.004; 01.01.02.0060.000119%Not Available
Thyroid disorder05.02.01.0020.000361%Not Available
Thyroid neoplasm16.24.01.002; 05.02.05.0020.000308%Not Available
Thyroiditis05.02.04.0010.000044%Not Available
Tinnitus17.04.07.004; 04.04.01.0020.000462%
Tongue discolouration07.14.02.0060.000088%Not Available
Tongue ulceration07.14.01.0030.000088%Not Available
Tooth deposit07.09.02.0040.000044%Not Available
Tooth discolouration07.09.02.0010.000172%
Tooth disorder07.09.05.0010.004799%Not Available
Tooth erosion07.09.05.0020.000044%Not Available
Tooth impacted07.09.08.0060.000088%Not Available
Tooth loss12.01.17.026; 07.09.09.0010.000969%Not Available
Toothache07.09.06.0010.000819%
Torticollis15.05.04.003; 17.01.03.0030.000066%Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Transient global amnesia19.20.01.004; 17.03.02.0040.000066%Not Available
Transient ischaemic attack24.04.06.005; 17.08.04.0010.000682%
Tricuspid valve incompetence02.07.05.0010.000308%Not Available
Trigeminal neuralgia17.04.08.0010.000066%Not Available
Trigger finger15.07.01.0050.000242%Not Available
Trismus17.01.03.004; 15.05.04.0040.000348%
Tympanic membrane perforation12.01.14.001; 04.05.04.0010.000132%Not Available
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