Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neuroma17.18.02.001; 16.09.02.0010.000110%Not Available
Neuropathy peripheral17.09.03.0030.001211%Not Available
Night sweats08.01.03.031; 23.02.03.0060.000132%Not Available
Nipple disorder21.05.04.0060.000044%
Nocturia20.02.03.0010.000528%Not Available
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.0010.000044%Not Available
Normochromic normocytic anaemia01.03.02.0050.000176%Not Available
Obesity14.03.02.0090.000330%
Ocular hyperaemia06.04.05.004--Not Available
Ocular hypertension06.03.01.0030.000044%Not Available
Odynophagia07.01.06.0360.000066%Not Available
Oedema14.05.06.010; 08.01.07.0060.000550%Not Available
Oedema mouth23.04.01.008; 10.01.05.006; 07.05.04.0010.000066%Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.0070.001937%
Oesophageal carcinoma16.13.06.001; 07.21.06.0010.000066%Not Available
Oesophageal haemorrhage24.07.02.021; 07.12.01.002--
Oesophageal obstruction07.13.02.0020.000044%
Oesophageal pain07.01.05.012--
Oesophageal spasm07.02.04.0040.000088%Not Available
Oesophageal stenosis07.13.02.0010.000154%
Oesophageal ulcer07.04.05.0020.000273%
Oesophagitis07.08.05.0010.000603%
Oestrogen deficiency21.11.02.003; 05.05.04.0030.000286%Not Available
Optic neuritis10.02.01.097; 17.04.05.001; 06.04.08.0020.000088%Not Available
Oral discomfort07.05.05.0010.000132%Not Available
Oral pain07.05.05.0340.000480%
Orthostatic hypotension24.06.03.004; 17.05.01.0200.000242%Not Available
Osteitis15.02.04.0150.000726%Not Available
Osteoarthritis15.01.04.0010.009972%Not Available
Osteochondrosis15.07.03.0020.000044%Not Available
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