Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Glossodynia07.14.02.0010.000808%Not Available
Glucose tolerance impaired14.06.02.001; 05.06.02.0010.001414%
Goitre14.11.01.008; 05.02.01.0010.001516%Not Available
Gout15.01.06.001; 14.09.01.0010.002526%Not Available
Gouty arthritis15.01.06.004; 14.09.01.0040.000303%Not Available
Granuloma23.03.15.001; 08.01.05.0010.000707%Not Available
Gravitational oedema08.01.07.005; 02.05.04.0140.000202%Not Available
Groin pain15.03.02.0040.002728%Not Available
Haemangioma24.03.06.004; 16.02.01.0020.000606%Not Available
Haemangioma of liver16.06.01.003; 09.04.01.003; 24.03.06.0060.000505%Not Available
Haemarthrosis24.07.01.046; 12.04.03.001; 15.01.01.0040.000707%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000909%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.001617%Not Available
Haematocrit decreased13.01.05.0010.001414%Not Available
Haematoma24.07.01.0010.003031%
Haematuria24.07.01.047; 20.02.01.0060.002829%
Blood urine present13.13.02.002--Not Available
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.0030.003031%Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Haemorrhage subcutaneous24.07.06.010; 23.06.07.0020.000303%Not Available
Haemorrhagic disorder24.07.01.021; 01.01.03.0040.000202%Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.006668%
Hair disorder23.02.06.0030.000202%Not Available
Hallucination19.10.02.002--
Hand fracture15.08.03.014; 12.04.01.0140.003536%Not Available
Head discomfort17.02.05.0270.000202%Not Available
Headache17.14.01.001--
Heart rate increased13.14.04.002--Not Available
Heart rate irregular13.14.04.0030.001111%Not Available
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