Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eye infection06.04.05.007; 11.01.06.0010.000606%
Eye pain06.08.03.002--
Eye swelling06.08.03.003--Not Available
Eyelid ptosis06.05.01.002; 17.17.02.0040.000606%Not Available
Facial bones fracture15.08.04.001; 12.04.05.0020.000606%Not Available
Facial pain08.01.08.0120.001010%
Facial paralysis17.04.03.0080.000303%Not Available
Faeces discoloured07.01.03.002--Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000105%Not Available
Fasciitis15.03.03.0010.000202%Not Available
Fatigue08.01.01.002--
Fear19.06.03.0010.001516%Not Available
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.009--Not Available
Feeling jittery08.01.09.016--Not Available
Femoral neck fracture12.04.01.002; 15.08.03.0020.004446%Not Available
Femur fracture15.08.03.003; 12.04.01.0030.249154%Not Available
Fibrin D dimer increased13.01.02.0360.000202%Not Available
Fibroadenoma of breast21.05.01.005; 16.14.01.0010.000505%Not Available
Fibrocystic breast disease21.05.01.002; 16.14.01.0030.002425%Not Available
Fibroma16.02.02.010; 15.09.01.0040.000303%Not Available
Fibrosis08.03.01.0010.000505%Not Available
Fistula15.03.02.0010.003637%Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.0070.000202%
Flatulence07.01.04.0020.001111%
Fluid overload14.05.06.001; 02.05.04.0040.000303%Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Food allergy10.01.01.0120.000404%Not Available
Foot fracture12.04.01.012; 15.08.03.0120.015863%Not Available
Fracture15.08.02.001; 12.04.02.0010.011720%
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