Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gravitational oedema02.05.04.014; 08.01.07.0050.000044%Not Available
Groin pain15.03.02.0040.000819%Not Available
Haemangioma24.03.06.004; 16.02.01.0020.000207%Not Available
Haemangioma of liver24.03.06.006; 16.06.01.003; 09.04.01.0030.000132%Not Available
Haemarthrosis24.07.01.046; 15.01.01.004; 12.04.03.0010.000176%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000264%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.000480%Not Available
Haematoma24.07.01.0010.000660%
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.0060.000638%
Haemoglobin13.01.05.018--Not Available
Haemoptysis02.11.04.009; 24.07.01.006; 22.02.03.004--Not Available
Haemorrhage subcutaneous24.07.06.010; 23.06.07.0020.000119%Not Available
Haemorrhagic disorder24.07.01.021; 01.01.03.0040.000066%Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.001453%
Hair disorder23.02.06.0030.000044%Not Available
Hallucination, auditory19.10.04.004--Not Available
Hallucination, visual19.10.04.007--Not Available
Head discomfort17.02.05.0270.000044%Not Available
Headache17.14.01.0010.002888%
Hemiparesis17.01.04.0010.000110%
Hepatic cirrhosis09.01.04.0010.000066%Not Available
Hepatic cyst16.06.02.001; 09.01.08.0080.000264%Not Available
Hepatic steatosis09.01.07.003; 14.08.04.0050.000286%Not Available
Hepatitis09.01.07.0040.000132%Not Available
Hepatitis toxic12.03.01.016; 09.01.07.0170.000066%Not Available
Hernia08.01.04.0010.000506%Not Available
Hiatus hernia22.09.02.004; 07.16.01.0010.001277%Not Available
Hirsutism05.05.01.005; 23.02.04.0010.000088%
Hydrocephalus17.07.01.0010.000044%
Hydronephrosis20.01.05.0010.000286%Not Available
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