Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ear disorder04.03.01.0010.000909%Not Available
Ear infection11.01.05.001; 04.03.01.0060.000808%Not Available
Ear pain04.03.01.0030.001414%
Eating disorder19.09.01.008; 14.03.01.0080.000909%Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.0010.002223%Not Available
Eczema23.03.04.0060.001212%
Electrocardiogram abnormal13.14.05.0010.001516%Not Available
Electrocardiogram QRS complex prolonged13.14.05.0030.000202%Not Available
Electrocardiogram ST segment abnormal13.14.05.0170.000404%Not Available
Electrolyte imbalance14.05.01.0020.000606%Not Available
Emotional disorder19.04.02.0050.000606%Not Available
Emphysema22.01.02.0020.000870%Not Available
Encephalopathy17.13.02.001--
Endometrial cancer21.07.02.002; 16.12.02.0010.000105%Not Available
Endometrial disorder21.07.01.0010.000303%Not Available
Endometrial hyperplasia21.07.01.0020.000202%Not Available
Endometriosis21.07.01.0040.000404%Not Available
Epicondylitis15.07.01.007; 12.01.07.0010.001414%Not Available
Epilepsy17.12.03.002--Not Available
Episcleritis10.02.01.024; 06.04.07.001--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.0030.000303%
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Essential hypertension24.08.02.0080.003637%Not Available
Essential tremor17.01.06.0040.000505%Not Available
Eustachian tube dysfunction04.05.02.0010.000211%Not Available
Exostosis15.02.04.0050.007275%
Extrasystoles02.03.02.0030.000505%Not Available
Eye disorder06.08.03.0010.002425%Not Available
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