| Drug Name |
Adapalene |
| Drug ID |
BADD_D00042 |
| Description |
Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. It is also associated with _Cutibacterium acnes_ (also known as _Propionibacterium acnes_). Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris.[A193518] Adapalene has similar efficacy but a superior safety profile compared to tretinoin.[A193521] [Tazarotene] is more efficacious than adapalene but is designated as pregnancy category X and hence is contraindicated in pregnant women.[A193518] Adapalene can also be combined with benzoyl peroxide (BPO), which possesses bactericidal properties[A193524], and either adapalene alone, or adapalene BPO combination products, are commonly used to treat mild-to-severe acne.[A193518]
Differin®, produced by Galderma Labs, was first granted FDA approval on May 31st, 1996, as a 0.1% adapalene topical solution. Differin was later made available as 0.1% gel, cream, or lotion, or 0.3% gel products. On December 8th, 2008, Galderma Labs gained FDA approval for Epiduo®, a 0.1% adapalene, 2.5% BPO combination gel.[L12873] |
| Indications and Usage |
For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back. |
| Marketing Status |
Prescription; OTC; Discontinued |
| ATC Code |
D10AD03 |
| DrugBank ID |
DB00210
|
| KEGG ID |
D01112
|
| MeSH ID |
D000068816
|
| PubChem ID |
60164
|
| TTD Drug ID |
D0JC9N
|
| NDC Product Code |
45802-453; 82034-888; 46014-1098; 0299-4910; 53296-0068; 0299-5915; 11673-888; 15308-0716; 68462-403; 51672-1377; 0363-0888; 51672-2143; 49967-591; 0472-0126; 36800-088; 0781-7142; 90027-010; 63629-8791; 71589-008; 24196-138; 70000-0043; 49967-354; 0299-5918; 55910-880; 21130-708; 0299-5912; 66039-801; 62332-549; 22365-120; 50090-2004; 71052-556; 0168-0424; 11410-956; 17337-0006; 66993-884; 42546-720; 41250-288; 59726-888 |
| Synonyms |
Adapalene | 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid | CD 271 | 271, CD | CD271 | CD-271 | Adaferin | Differin | Differine |
