Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage Zouboulis CC: Retinoids--which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
Marketing Status Prescription; Discontinued
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 42291-088; 0145-0091; 17337-0004; 76055-0001; 71214-0668; 0093-1136; 0093-1135; 58159-058; 42794-081; 42794-080; 0093-1138; 0145-0090; 62147-0145; 42794-083; 42291-086; 71214-0667; 71214-0669; 0378-7020; 0115-1750; 0115-1751; 0115-1752; 71214-0698; 42291-087; 62147-0146; 0378-7023; 17337-0003; 59981-011; 0115-1753
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Psoriatic arthropathy15.01.10.001; 10.02.01.031; 23.03.14.0050.014320%Not Available
Pulmonary embolism22.06.02.001; 24.01.06.0010.005728%Not Available
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pustular psoriasis23.03.14.0060.008592%Not Available
Pyogenic granuloma24.03.06.002; 23.10.01.001; 16.26.01.001; 07.20.02.004--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.0010.011456%Not Available
Rash erythematous23.03.06.003--Not Available
Red blood cell count decreased13.01.05.007--Not Available
Red blood cell count increased13.01.05.008--Not Available
Red blood cells urine positive13.13.02.003--Not Available
Reticulocyte count decreased13.01.05.009--Not Available
Reticulocyte count increased13.01.05.010--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Rhinitis11.01.13.004; 22.07.03.006--
Rickets15.02.03.006; 14.04.04.0050.008592%Not Available
Saliva altered07.06.01.004--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Scab23.03.03.004--Not Available
Scleroderma23.03.02.005; 15.06.01.002; 10.04.07.001--Not Available
Seborrhoea23.02.07.001--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
Sepsis11.01.11.0030.002241%
Sinusitis11.01.13.005; 22.07.03.007--
Skin atrophy23.01.05.001--
Skin disorder23.03.03.0070.005728%Not Available
Skin erosion23.07.03.0020.005728%Not Available
Skin exfoliation23.03.07.0030.022911%Not Available
Skin fissures23.03.03.008--Not Available
Skin fragility23.03.03.009--Not Available
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