Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage Zouboulis CC: Retinoids--which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
Marketing Status Prescription; Discontinued
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 42291-088; 0145-0091; 17337-0004; 76055-0001; 71214-0668; 0093-1136; 0093-1135; 58159-058; 42794-081; 42794-080; 0093-1138; 0145-0090; 62147-0145; 42794-083; 42291-086; 71214-0667; 71214-0669; 0378-7020; 0115-1750; 0115-1751; 0115-1752; 71214-0698; 42291-087; 62147-0146; 0378-7023; 17337-0003; 59981-011; 0115-1753
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bursitis15.04.01.001--Not Available
Capillary leak syndrome24.06.03.001; 08.01.07.012--
Cardiac failure congestive02.05.01.0020.005728%Not Available
Cataract06.06.01.0010.008592%
Cataract subcapsular06.06.01.002--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chalazion06.04.04.002--Not Available
Cheilitis23.03.03.025; 07.05.01.0010.005728%
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholestasis09.01.01.0010.014320%Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Congenital anomaly03.02.01.001--Not Available
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Corneal epithelium defect06.06.03.012--Not Available
Corneal lesion06.06.03.004--Not Available
Cough22.02.03.001--
Creatinine renal clearance decreased13.13.01.0130.005728%Not Available
Crohn's disease10.02.01.005; 07.08.01.0150.005728%Not Available
Cushing's syndrome05.01.01.001; 24.08.04.001; 19.07.03.002; 14.11.01.0070.022911%Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Cyst08.03.05.001; 16.02.02.002--Not Available
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Depressed mood19.15.02.0010.005728%Not Available
Depression19.15.01.0010.008592%
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
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