Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abciximab
Drug ID BADD_D00013
Description Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.
Indications and Usage Abciximab is indicated as an adjunct to percutaneous coronary intervention for the prevention of cardiac ischemic complications in patients undergoing percutaneous coronary intervention and in patients with unstable angina not responding to conventional medical therapy when percutaneous coronary intervention is planned within 24 hours. Abciximab is intended for use with aspirin and heparin and has been studied only in that setting.
Marketing Status Prescription
ATC Code B01AC13
DrugBank ID DB00054
KEGG ID D02778
MeSH ID D000077284
PubChem ID Not Available
NDC Product Code Not Available
Synonyms Abciximab | c7E3 Fab | Chimeric 7E3 Fab | Fab, Chimeric 7E3 | ReoPro | Clotinab | CentoRx
Chemical Information
Molecular Formula Not Available
CAS Registry Number 143653-53-6
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresIntegrin alpha-IIbP08514Not Available10195947; 11447076; 11151063; 11425767
Surgical and medical proceduresIntegrin beta-3P05106T2645710195947; 11447076; 11151063; 11425767
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abscess11.01.08.001--Not Available
Arteriovenous fistula24.03.03.001--Not Available
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.003--
Back pain15.03.04.005--
Bladder pain20.02.02.001--Not Available
Bradycardia02.03.02.002--Not Available
Cellulitis23.09.01.001; Available
Cerebrovascular accident24.03.05.001;
Chest pain02.02.02.011;; Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001;
Dermatitis bullous23.03.01.002--
Diabetes mellitus14.06.01.001; Available
Diplopia17.17.01.005; Available
Dry mouth07.06.01.002--
Gastrooesophageal reflux disease07.02.02.003--
Haemorrhage intracranial24.07.04.003;
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