| ADR Ontology |
| ADR Term |
Testotoxicosis |
| ADR ID |
BADD_A08703 |
| ADR Hierarchy |
|
| Description |
Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. | An autosomal dominant hereditary disorder that is characterized by gonadotropin-dependent precocious puberty due to early activation of the hypothalamic-pituitary-gonadal axis. A mutation in the KISS1R gene has been identified. OMIM: 176400 | Familial precocious puberty in boys usually presents by age 4 with rapid VIRILIZATION and is also characterized by gonadotropin-independent testosterone secretion, low secretion of LUTEINIZING HORMONE, and advanced SPERMATOGENESIS in the testis. Mutations in the LHCGR gene have been identified. OMIM: 176410 [MeSH] |
| MedDRA Code |
10063654 |
| MeSH ID |
D011629
|
|
ADR Severity Grade (FAERS)
|
|
|
ADR Severity Grade (CTCAE)
|
Not Available
|
| Synonym |
| Testotoxicosis | Gonadotrophin-independent male sexual precocity | Puberty, Precocious | Precocious Puberties | Puberties, Precocious | Pubertas Praecox | Praecox, Pubertas | Precocious Puberty | Precocious Puberty, Central | Central Precocious Puberties | Central Precocious Puberty | Precocious Puberties, Central | Puberties, Central Precocious | Puberty, Central Precocious | Sexual Precocity | Precocities, Sexual | Precocity, Sexual | Sexual Precocities | Idiopathic Sexual Precocity | Idiopathic Sexual Precocities | Precocities, Idiopathic Sexual | Precocity, Idiopathic Sexual | Sexual Precocities, Idiopathic | Sexual Precocity, Idiopathic | Familial Precocious Puberty | Familial Precocious Puberties | Precocious Puberties, Familial | Precocious Puberty, Familial | Puberties, Familial Precocious | Puberty, Familial Precocious | Precocious Puberty, Male-Limited | Male-Limited Precocious Puberties | Male-Limited Precocious Puberty | Precocious Puberties, Male-Limited | Puberties, Male-Limited Precocious | Puberty, Male-Limited Precocious | Precocious Puberty, Male Limited |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
|
| Drugs Leading to the ADR |
| Drug ID | Drug Name | ADR Frequency (FAERS) | ADR Severity Grade (FAERS) | | BADD_D00329 | Cabergoline | 0.077071% | |
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