Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term POEMS syndrome
ADR ID BADD_A08178
ADR Hierarchy
01      Blood and lymphatic system disorders
01.14      Plasma cell neoplasms
01.14.02      Plasma cell myelomas
01.14.02.005      POEMS syndrome
05      Endocrine disorders
05.09      Endocrine and glandular disorders NEC
05.09.01      Endocrine disorders NEC
05.09.01.003      POEMS syndrome
10      Immune system disorders
10.04      Autoimmune disorders
10.04.10      Nervous system autoimmune disorders
10.04.10.016      POEMS syndrome
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.23      Plasma cell neoplasms
16.23.02      Plasma cell myelomas
16.23.02.005      POEMS syndrome
17      Nervous system disorders
17.09      Peripheral neuropathies
17.09.03      Peripheral neuropathies NEC
17.09.03.020      POEMS syndrome
Description A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62) [MeSH]
MedDRA Code 10053869
MeSH ID D016878
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
POEMS syndrome | Crow-Fukase syndrome | Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes | POEMS Syndrome | Syndrome, POEMS | Takatsuki's Syndrome | Syndrome, Takatsuki's | Takatsuki Syndrome | Polyneuropathy Organomegaly | Organomegalies, Polyneuropathy | Organomegaly, Polyneuropathy | Polyneuropathy Organomegalies | Crow-Fukase Syndrome | Crow Fukase Syndrome | Syndrome, Crow-Fukase | Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01253Lenalidomide0.001326%
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