Adverse Drug Reaction Classification System

ADR Ontology
ADR Term SAPHO syndrome
ADR ID BADD_A08025
ADR Hierarchy
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.064      SAPHO syndrome
15      Musculoskeletal and connective tissue disorders
15.03      Musculoskeletal and connective tissue disorders NEC
15.03.03      Musculoskeletal and connective tissue infections and inflammations NEC
15.03.03.013      SAPHO syndrome
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.10      Pustular conditions
23.03.10.005      SAPHO syndrome
Description Syndrome consisting of SYNOVITIS; ACNE CONGLOBATA; PALMOPLANTAR PUSTULOSIS; HYPEROSTOSIS; and OSTEITIS. The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome. [MeSH]
MedDRA Code 10051316
MeSH ID D020083
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
SAPHO syndrome | Acquired Hyperostosis Syndrome | Acquired Hyperostosis Syndromes | Hyperostosis Syndrome, Acquired | Hyperostosis Syndromes, Acquired | Syndrome, Acquired Hyperostosis | Syndromes, Acquired Hyperostosis | Synovitis, Acne, Pustlosis, Hyperostosis, and Osteomyelitis | SAPHO Syndrome | SAPHO Syndromes | Syndrome, SAPHO | Syndromes, SAPHO
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00195Azathioprine0.002154%
BADD_D01213Isotretinoin0.002526%
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