| ADR Ontology |
| ADR Term |
Locked-in syndrome |
| ADR ID |
BADD_A07365 |
| ADR Hierarchy |
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| Description |
A syndrome characterized by a silent and inert state without voluntary motor activity despite preserved sensorimotor pathways and vigilance. Bilateral FRONTAL LOBE dysfunction involving the anterior cingulate gyrus and related brain injuries are associated with this condition. This may result in impaired abilities to communicate and initiate motor activities. (From Adams et al., Principles of Neurology, 6th ed, p348; Fortschr Neurol Psychiatr 1995 Feb;63(2):59-67) [MeSH] |
| MedDRA Code |
10024792 |
| MeSH ID |
D000405; D011782; D011782
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Not Available
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| Synonym |
| Akinetic mutism | Locked-in state | Locked-in syndrome | Akinetic Mutism | Mutism, Akinetic | Akinetic Mutisms | Coma Vigilans | Akinetic Autism | Autism, Akinetic | Coma Vigil | Vigil, Coma | Vigils, Coma |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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