Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Kearns-Sayre syndrome
ADR ID BADD_A04735
ADR Hierarchy
02      Cardiac disorders
02.04      Myocardial disorders
02.04.01      Cardiomyopathies
02.04.01.006      Kearns-Sayre syndrome
03      Congenital, familial and genetic disorders
03.18      Cytoplasmic disorders congenital
03.18.01      Genetic mitochondrial abnormalities NEC
03.18.01.001      Kearns-Sayre syndrome
06      Eye disorders
06.05      Ocular neuromuscular disorders
06.05.02      Ocular nerve and muscle disorders
06.05.02.016      Kearns-Sayre syndrome
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.05      Myopathies
15.05.05.009      Kearns-Sayre syndrome
17      Nervous system disorders
17.17      Neurological disorders of the eye
17.17.01      Neurologic visual problems NEC
17.17.01.019      Kearns-Sayre syndrome
Description A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) with conduction block (HEART BLOCK), and RETINITIS PIGMENTOSA. Disease onset is in the first or second decade. Elevated CSF protein, sensorineural deafness, seizures, and pyramidal signs may also be present. Ragged-red fibers are found on muscle biopsy. (Adams et al., Principles of Neurology, 6th ed, p984) [MeSH]
MedDRA Code 10048804
MeSH ID D007625
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Kearns-Sayre syndrome | Kearns-Sayre Syndrome | Syndrome, Kearns-Sayre | CPEO with Myopathy | CPEO with Myopathies | Myopathies, CPEO with | Myopathy, CPEO with | CPEO with Ragged Red Fibers | Cpeo With Ragged-Red Fibers | Kearn-Sayre Mitochondrial Cytopathy | Cytopathy, Kearn-Sayre Mitochondrial | Kearn Sayre Mitochondrial Cytopathy | Mitochondrial Cytopathy, Kearn-Sayre | Kearns Sayre Syndrome | Sayre Syndrome, Kearns | Syndrome, Kearns Sayre | Kearns Syndrome | Syndrome, Kearns | Kearns' Syndrome | Kearn Syndrome | Syndrome, Kearns' | Kearns-Sayre-Shy-Daroff Syndrome | Kearns Sayre Shy Daroff Syndrome | Syndrome, Kearns-Sayre-Shy-Daroff | Oculocraniosomatic Syndrome | Oculocraniosomatic Syndromes | Syndrome, Oculocraniosomatic | Ophthalmoplegia Plus Syndrome | Ophthalmoplegia Plus Syndromes | Syndrome, Ophthalmoplegia Plus | Ophthalmoplegia, Pigmentary Degeneration of Retina, and Cardiomyopathy | Ophthalmoplegia, Progressive External, With Ragged-Red Fibers | Ophthalmoplegia-Plus Syndrome | Kearns-Sayre Mitochondrial Cytopathy | Chronic Progressive External Ophthalmoplegia with Myopathy
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00170Articaine hydrochloride--
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