Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Splenic rupture
ADR ID BADD_A04137
ADR Hierarchy
01      Blood and lymphatic system disorders
01.09      Spleen, lymphatic and reticuloendothelial system disorders
01.09.02      Spleen disorders
01.09.02.006      Splenic rupture
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.02      Abdominal injuries NEC
12.01.02.004      Splenic rupture
Description Rupture of the SPLEEN due to trauma or disease. [MeSH]
MedDRA Code 10041658
MeSH ID D013161
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Capsular tears to spleen, w/o major disruption of parenchyma, w/o ment of open wound into cavity | Capsular tears to spleen, without major disruption of parenchyma, with open wound into cavity | Injury to spleen with open wound into cavity | Laceration of spleen extending into parenchyma without mention of open wound into cavity | Laceration of spleen extending into parenchyma, with open wound into cavity | Massive parenchyma disruption of spleen with open wound into cavity | Massive parenchymal disruption of spleen without mention of open wound into cavity | Other injury to spleen with open wound into cavity | Rupture of spleen | Rupture spleen | Spleen rupture of | Splenic rupture | Unspecified injury to spleen with open wound into cavity | Splenic laceration | Splenic Rupture | Rupture, Splenic | Ruptures, Splenic | Splenic Ruptures
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00151Apixaban0.000795%
BADD_D00195Azathioprine0.001436%
BADD_D00504Clopidogrel0.000205%
BADD_D00564Dabigatran etexilate0.021624%
BADD_D00648Diazepam0.000056%
BADD_D00680Dimethyl fumarate0.002751%
BADD_D00692Dipyridamole0.008948%
BADD_D00897Filgrastim--
BADD_D01060Heparin0.016698%
BADD_D01119Ibrutinib0.002664%
BADD_D01136Imatinib0.001066%
BADD_D01253Lenalidomide--
BADD_D01567Nilotinib0.000799%
BADD_D01693Pegfilgrastim--
BADD_D01788Plerixafor0.007719%
BADD_D01799Ponatinib0.000533%
BADD_D01835Pregabalin--
BADD_D01954Rivaroxaban0.008210%
BADD_D01978Ruxolitinib0.001598%
BADD_D02070Streptokinase--
BADD_D02170Testosterone0.000594%
BADD_D02373Warfarin0.000841%
BADD_D02434Cinacalcet--
BADD_D02464Fingolimod0.001737%
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