Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cervical incompetence
ADR ID BADD_A00864
ADR Hierarchy
18      Pregnancy, puerperium and perinatal conditions
18.02      Maternal complications of pregnancy
18.02.02      Maternal complications of pregnancy NEC
18.02.02.009      Cervical incompetence
21      Reproductive system and breast disorders
21.06      Cervix disorders (excl infections and inflammations)
21.06.01      Cervix disorders NEC
21.06.01.008      Cervical incompetence
Description Incompetent UTERINE CERVIX is usually diagnosed in the second trimester of PREGNANCY. It is characterized by passive painless cervical dilation in the absence of UTERINE CONTRACTION; BLEEDING; INFECTION; and sometimes with the amniotic sac (AMNIOTIC MEMBRANE) bulging through the partially dilated cervix. Left untreated, this condition may lead to premature pregnancy loss, such as HABITUAL ABORTION. [MeSH]
MedDRA Code 10008267
MeSH ID D002581
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cervical incompetence | Cervical incompetence (complicating pregnancy) | Cervical incompetence complicating pregnancy, childbirth, or the puerperium | Cervical incompetence, antepartum condition or complication | Cervical incompetence, delivered, with mention of postpartum complication | Cervical incompetence, postpartum condition or complication | Cervical incompetence, unspecified as to episode of care in pregnancy | Cervical incompetence, with delivery | Incompetence of cervix | Incompetent cervix | Incompetent cervix affecting fetus or newborn | Bulging amniotic membranes | Uterine Cervical Incompetence | Cervical Incompetence, Uterine | Incompetence, Uterine Cervical | Cervix Incompetence | Incompetence, Cervix | Incompetent Cervix | Cervices, Incompetent | Cervix, Incompetent | Incompetent Cervices
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00277Bisoprolol0.003354%
BADD_D00475Citalopram0.000125%
BADD_D00720Doxepin0.001036%
BADD_D00734Duloxetine0.000198%
BADD_D00932Fluoxetine0.000227%
BADD_D01106Hydroxyprogesterone--
BADD_D01107Hydroxyprogesterone caproate-
BADD_D01281Levonorgestrel0.004169%
BADD_D01401Metformin0.000039%
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