Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Breast tenderness21.05.05.0040.000381%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.001858%Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.0090.000336%Not Available
Cardiac failure02.05.01.0010.002574%
Cardiac failure acute02.05.01.0050.000560%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac hypertrophy02.04.02.0170.000112%Not Available
Cardiomegaly02.04.02.0010.000358%Not Available
Cardiomyopathy02.04.01.0010.000448%Not Available
Cataract06.06.01.0010.000806%
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebral ischaemia17.08.01.005; 24.04.06.0030.000112%
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000112%Not Available
Cheilitis23.03.03.025; 07.05.01.0010.000571%
Chest pain02.02.02.011; 22.12.02.003; 08.01.08.0020.003559%Not Available
Chills15.05.03.016; 08.01.09.001--
Cholangitis09.02.01.0020.000168%Not Available
Cholecystitis09.03.01.0010.000392%
Cholecystitis acute09.03.01.0030.000168%Not Available
Cholestasis09.01.01.0010.001175%Not Available
Chromaturia20.02.01.0020.001679%
Chronic myeloid leukaemia16.01.07.001; 01.10.07.0010.000168%Not Available
Colitis07.08.01.001--
Coma17.02.09.001--Not Available
Constipation07.02.02.0010.007980%
Cough22.02.03.0010.006917%
Cyst16.02.02.002; 08.03.05.001--Not Available
Deafness04.02.01.0010.000526%Not Available
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